A 1H magnetic resonance spectroscopy study in patients with obstructive sleep apnea

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
P SarchielliP Calabresi

Abstract

Repeated episodes of hypoxia, hypercapnia and transient blood pressure elevation in obstructive sleep apnea syndrome (OSAS) may damage neutral structures and induce cerebral metabolic impairment. This study aimed to determine the impact of OSAS on cerebral metabolites measured by (1)H magnetic resonance spectroscopy ((1)H -MRS). Twenty OSAS patients underwent standard overnight polysomnography and (1)H-MRS separately. Proton volumes of interest (VOIs) were placed in frontal and midtemporal regions bilaterally. Significantly lower values of the N-acetylaspartate (NAA)/creatine (Cr) ratio were found in frontal regions (P < 0.004) compared with 20 age-matched control subjects. A significant increase in the myo-inositol (Ins)/Cr ratio was evident bilaterally in temporal and frontal regions (P < 0.00002 and P < 0.04). Choline (Cho)/Cr ratio values were also significantly greater in temporal regions (P < 0.00001). A significant negative correlation (r = -0.51, P < 0.03) was found between the apnea-hypopnea index (AHI) and NAA/Cr ratio in the frontal regions of OSAS patients. Reduction in the NAA/Cr ratio in frontal regions of OSAS patients could be related to neural loss. Increase in the Cho/Cr ratio in temporal regions and Ins/Cr ra...Continue Reading

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Citations

Apr 11, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·L Ferini-StrambiC Castronovo
Dec 17, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Galip AkhanSerdar Kalemci
Jul 6, 2017·NMR in Biomedicine·Ivan I KirovOded Gonen
May 3, 2014·Sleep·Santosh K YadavRonald M Harper
Jun 21, 2012·Journal of Neuroscience Research·Rajesh KumarRonald M Harper
Aug 14, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A G ChuchalinL V Shogenova
Sep 4, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jose A PalomaresRajesh Kumar
Aug 14, 2018·NeuroImage. Clinical·Paul M MaceyRonald M Harper
Sep 1, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Alice RegnaudFrançois Lazeyras

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