PMID: 15341175Sep 3, 2004Paper

A 2-D model of flow-induced alterations in the geometry, structure, and properties of carotid arteries

Journal of Biomechanical Engineering
R L GleasonJ D Humphrey

Abstract

Evidence from diverse investigations suggests that arterial growth and remodeling correlates well with changes in mechanical stresses from their homeostatic values. Ultimately, therefore, there is a need for a comprehensive theory that accounts for changes in the 3-D distribution of stress within the arterial wall, including residual stress, and its relation to the mechanisms of mechanotransduction. Here, however, we consider a simpler theory that allows competing hypotheses to be tested easily, that can provide guidance in the development of a 3-D theory, and that may be useful in modeling solid-fluid interactions and interpreting clinical data. Specifically, we present a 2-D constrained mixture model for the adaptation of a cylindrical artery in response to a sustained alteration in flow. Using a rule-of-mixtures model for the stress response and first order kinetics for the production and removal of the three primary load-bearing constituents within the wall, we illustrate capabilities of the model by comparing responses given complete versus negligible turnover of elastin. Findings suggest that biological constraints may result in suboptimal adaptations, consistent with reported observations. To build upon this finding, how...Continue Reading

References

Jan 1, 1975·Cardiology·S Rodbard
Jan 1, 1977·Experimental Gerontology·H NiedermüllerA Kment
Jul 1, 1991·Canadian Journal of Physiology and Pharmacology·R D Brownlee, B L Langille
Oct 1, 1990·Physiological Reviews·S M SchwartzM W Majesky
Apr 1, 1989·The American Journal of Physiology·B L LangilleF W Keeley
May 1, 1986·Journal of Biomechanical Engineering·C J Chuong, Y C Fung
Feb 7, 1988·Journal of Theoretical Biology·A Tözern, R Skalak
Mar 1, 1987·Journal of Vascular Surgery·C K ZarinsS Glagov
Jul 1, 1980·The American Journal of Physiology·A Kamiya, T Togawa
Jul 1, 1995·Physiological Reviews·P F Davies
Jan 1, 1993·Journal of Cardiovascular Pharmacology·B L Langille
Feb 1, 1995·Circulation Research·A ChoB L Langille
May 1, 1994·Annals of Biomedical Engineering·H AchakriJ J Meister
Apr 1, 1994·Journal of Biomechanics·E K RodriguezA D McCulloch
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·F TroncA Tedgui
Jan 1, 1997·Annual Review of Physiology·K R Stenmark, R P Mecham
Sep 12, 1998·The Journal of Surgical Research·T M SinghC K Zarins
Jul 21, 1999·Journal of Biomechanical Engineering·L A Taber
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·H MasudaS Glagov
Jan 7, 2000·Annals of Biomedical Engineering·P RoyJ V Jester
Jan 14, 2000·Journal of Biomechanical Engineering·J D Humphrey
May 4, 2000·The American Journal of Pathology·K J HarmonV Lindner
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·F TroncA Tedgui
Jun 16, 2001·Journal of Vascular Research·N StergiopulosS E Greenwald
May 4, 2002·Circulation Research·Zane S JacksonB Lowell Langille
Apr 5, 2003·Circulation Research·Jamila IbrahimBradford C Berk
Oct 31, 2003·Biomechanics and Modeling in Mechanobiology·J D Humphrey, K R Rajagopal

❮ Previous
Next ❯

Citations

Sep 6, 2007·Biomechanics and Modeling in Mechanobiology·Patrick W AlfordLarry A Taber
Dec 7, 2007·Biomechanics and Modeling in Mechanobiology·P N Watton, N A Hill
Jan 6, 2009·Biomechanics and Modeling in Mechanobiology·L CardamoneJ D Humphrey
Nov 28, 2009·Biomechanics and Modeling in Mechanobiology·H SchmidM Itskov
Dec 30, 2009·Biomechanics and Modeling in Mechanobiology·William WanRudolph L Gleason
Jan 13, 2010·Biomechanics and Modeling in Mechanobiology·Tim RickenOlaf Dirsch
May 18, 2010·Biomechanics and Modeling in Mechanobiology·Alexander Rachev, Rudolph L Gleason
Nov 4, 2010·Biomechanics and Modeling in Mechanobiology·Jessica E Wagenseil
May 16, 2012·Biomechanics and Modeling in Mechanobiology·Jeffrey K Cheng, Jessica E Wagenseil
May 10, 2007·Annals of Biomedical Engineering·J D HumphreyL E Niklason
Apr 8, 2009·Annals of Biomedical Engineering·J F EberthJ D Humphrey
Aug 4, 2009·Medical & Biological Engineering & Computing·Arturo Valentín, Jay D Humphrey
Sep 17, 2008·Computer Methods in Biomechanics and Biomedical Engineering·Patrick W Alford, Larry A Taber
Apr 12, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Shahrokh Zeinali-DavaraniSeungik Baek
Feb 25, 2011·Computer Methods in Biomechanics and Biomedical Engineering·H SchmidM Itskov
May 21, 2010·Mathematical Medicine and Biology : a Journal of the IMA·L CardamoneJ D Humphrey
Jul 24, 2008·Journal of the Royal Society, Interface·A ValentínJ D Humphrey
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A Valentín, J D Humphrey
Oct 17, 2009·Journal of Biomechanical Engineering·A Valentín, J D Humphrey
Oct 17, 2009·Journal of Biomechanical Engineering·Laura HansenRudolph L Gleason
Dec 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·William Wan, Rudolph L Gleason
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Yunlong HuoGhassan S Kassab
Jul 9, 2009·Physiological Reviews·Jessica E Wagenseil, Robert P Mecham
Jul 20, 2012·Annual Review of Biomedical Engineering·G A Ateshian, J D Humphrey
Feb 15, 2014·Biomechanics and Modeling in Mechanobiology·Victoria P LeJessica E Wagenseil
Mar 20, 2010·Biomechanics and Modeling in Mechanobiology·I M MachyshynF N van de Vosse
Oct 3, 2012·Journal of the Mechanical Behavior of Biomedical Materials·A GizziS Filippi
Jun 26, 2012·Journal of Theoretical Biology·Rachele Allena, Denis Aubry
Jun 20, 2012·Mechanics Research Communications·A Valentín, G A Holzapfel
Feb 4, 2012·Journal of the Mechanical Behavior of Biomedical Materials·V Kefalas, D A Eftaxiopoulos
Dec 20, 2011·Mechanics of Materials : an International Journal·Igor Karšaj, Jay D Humphrey
Aug 19, 2015·Journal of Biomechanics·Kerianne E SteuckePatrick W Alford
Feb 3, 2009·Journal of Biomechanics·Alkiviadis Tsamis, Nikos Stergiopulos
Jul 26, 2008·Journal of Biomechanics·Hai-Chao Han
Jul 17, 2007·Journal of Theoretical Biology·I HaritonG A Holzapfel
Sep 27, 2015·Medical Image Analysis·Fabrizio DonatiDavid A Nordsletten
Jan 16, 2014·International Journal for Numerical Methods in Biomedical Engineering·P AparícioP N Watton
Jul 4, 2006·Journal of Biomechanics·José J MuñozMark Miodownik
Aug 27, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Matthew A WyczalkowskiLarry A Taber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.