A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6

Genomics
M G BrownW M Yokoyama

Abstract

We have constructed a physical map of a > 2-Mb region on mouse chromosome 6 that contains the natural killer gene complex (NKC). The map comprises a contig of 14 overlapping yeast artificial chromosomes onto which we positioned 25 NKC markers. NKC genetically linked genes encode > 17 proteins that directly control innate NK cell-mediated tumor lysis and disease resistance. Herein we show that Nkrp1 genes are clustered in a region flanked by A2m and Cd69 genes and that most Ly49 genes are clustered in a distal region -1 Mb distant. Importantly, syntenic intervals of mouse chromosome 6 and human chromosome 12p that include the NKC are conserved. NKC species conservation suggests that the human NKC may contain orthologues for the mouse viral disease resistance genes, Cmv1 and Rmp1. The high-resolution NKC map will facilitate investigation of NKC gene regulation and identification of phenotypically defined gene products that confer NK cell defense against viral pathogens.

References

Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C HillikerH Van den Berghe
May 1, 1990·The Journal of Experimental Medicine·F TriebelT Hercend
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S K BronsonD D Chaplin
May 1, 1990·The Journal of Experimental Medicine·A A ScalzoG R Shellam
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R D HansonT J Ley
Jan 1, 1985·Annual Review of Biochemistry·S Karlsson, A W Nienhuis
Jan 1, 1989·Advances in Immunology·G Trinchieri
Feb 11, 1985·Nucleic Acids Research·E C ZwarthoffJ Trapman
Nov 16, 1995·Nature·J E Gumperz, P Parham
Aug 1, 1993·Current Opinion in Immunology·G J Bancroft
Feb 1, 1993·Current Opinion in Immunology·W M Yokoyama
Mar 14, 1996·Nature·W F DietrichT J O'Connor
May 1, 1996·Genomics·R W DeBry, M F Seldin
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·C T PhamT J Ley

❮ Previous
Next ❯

Citations

Jun 10, 1998·Immunology and Cell Biology·A Reichlin, W M Yokoyama
Apr 2, 1999·Immunology and Cell Biology·H S Warren, M J Smyth
Dec 22, 1998·The Journal of Experimental Medicine·A H IdrisW M Yokoyama
Jun 5, 2003·The Journal of Experimental Medicine·Ingunn H WestgaardSigbjorn Fossum
May 23, 1998·Annual Review of Immunology·L L Lanier
Jun 8, 1999·Annual Review of Immunology·E O Long
Jan 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Noriko Toyama-SorimachiHajime Karasuyama
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·E L HoW M Yokoyama
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·T IkawaY Yokota
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·A H IdrisW M Yokoyama
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J WilsonJ Trowsdale
Jul 22, 2008·Seminars in Immunology·Michael G Brown, Anthony A Scalzo
Jul 4, 2008·Seminars in Immunology·James R CarlyleAndrew P Makrigiannis
Mar 13, 2014·International Journal of Cancer. Journal International Du Cancer·Alejandro López-SotoSegundo Gonzalez
Nov 4, 2008·European Journal of Immunology·Stipan JonjićAstrid Krmpotić
Dec 21, 2004·Molecular Immunology·Daniel M AndrewsMariapia A Degli-Esposti
Aug 19, 2015·Immunological Reviews·Mir Munir A Rahim, Andrew P Makrigiannis
Sep 25, 1999·Seminars in Immunology·W HeldB Lowin-Kropf
Apr 26, 2014·Frontiers in Immunology·Mir Munir A RahimAndrew P Makrigiannis
Feb 13, 2010·Viruses·Joseph C Sun, Lewis L Lanier
Jul 11, 1998·The Journal of Biological Chemistry·S G BalchS Gordon
May 22, 2002·Nature Immunology·Astrid KrmpotićStipan Jonjić
Feb 6, 2018·Cellular & Molecular Immunology·Kushal PrajapatiJose A Guevara-Patino
Oct 3, 2003·Nature Reviews. Immunology·David H Raulet
Dec 18, 2018·Journal of Cellular Biochemistry·Solmaz ShirjangMehdi Yousefi
Apr 2, 2003·Nature Reviews. Immunology·Wayne M Yokoyama, Beatrice F M Plougastel
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonas SundbäckKlas Kärre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.