A 2-year study of lipid and lipoprotein changes in postmenopausal women with tibolone and estrogen-progestin

Obstetrics and Gynecology
M H MilnerR F Harrison

Abstract

To assess changes in lipid-lipoprotein profile in postmenopausal women taking tibolone and estrogen-progestin, compared with untreated controls. Sixty-three women were randomized to take a combined estrogen-progestin preparation (n = 31) or tibolone (n = 32), and 50 other women acted as controls. Fasting lipid-lipoprotein levels were measured over 96 weeks. The controls, who were older and postmenopausal longer than the therapy subjects, exhibited significant decreases in total (P < .05) and low-density lipoprotein (LDL) (P < .001) cholesterol and increases in triglyceride (P < .05) and lipoprotein (a) (P < .001) over the 96-week period of study. Lipoprotein (a) also decreased significantly in both treated groups (P < .001). Total and LDL cholesterol decreased and triglyceride increased in the estrogen-progestin group, but, compared with controls, these changes were not significant. Total cholesterol decreased in the tibolone group, although decreases in low- and particularly high-density lipoprotein (HDL) (P < .001) cholesterol and parallel decreases in apolipoprotein A1 (P < .001) and B (p < .01) were also observed. There was evidence of a reversion phenomenon in apolipoproteins A1 and B in all groups, and in lipoprotein (a) ...Continue Reading

References

Jan 1, 1992·Atherosclerosis·D CrookJ C Stevenson
Sep 21, 1991·BMJ : British Medical Journal·E FarishD M Hart
Jun 1, 1990·The Journal of Clinical Investigation·A M Scanu, G M Fless
Apr 1, 1990·Maturitas·H J KloosterboerP M Kicovic
Jun 1, 1988·American Journal of Obstetrics and Gynecology·R M KraussD Petitti
Jun 19, 1986·The New England Journal of Medicine·R J ChetkowskiH L Judd
Feb 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C J KimY K Min
Jan 4, 1993·Atherosclerosis·J C StevensonI F Godsland

❮ Previous
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Citations

Feb 5, 1999·Obstetrics and Gynecology·F Al-AzzawiT Mason
Jan 9, 1999·Maturitas·P AlbertazziE Zanardi
Mar 19, 2005·Clinical calcium·Itsuo Gorai
Feb 24, 2001·Journal of the American Geriatrics Society·H K KamelJ E Morley
Oct 16, 2001·Clinical Obstetrics and Gynecology·O Khorram
Jan 23, 1999·Pharmacotherapy·M B O'Connell
Aug 2, 2005·Lancet·Martha HickeyDavid W Sturdee
Feb 5, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L FedeleG Zanconato
Jul 18, 2015·Atherosclerosis·Kazuhiko KotaniUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Nov 11, 2008·Maturitas·Christel RenouxSamy Suissa
Sep 7, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G E ChristodoulakosG C Creatsas
Mar 21, 2001·Menopause : the Journal of the North American Menopause Society·P ZandbergD G Meuleman
Jul 24, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J M Rymer
Mar 18, 2004·The Annals of Pharmacotherapy·John M Swegle, Michael W Kelly
Aug 6, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S KalogeropoulosG Kalogeropoulos
Apr 19, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Changyu LvXiaohong Wang

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