A 20-Year Prospective Longitudinal Study of Degeneration of the Cervical Spine in a Volunteer Cohort Assessed Using MRI: Follow-up of a Cross-Sectional Study

The Journal of Bone and Joint Surgery. American Volume
Kenshi DaimonKota Watanabe

Abstract

Few studies have addressed in detail long-term degenerative changes in the cervical spine. In this study, we evaluated the progression of degenerative changes of the cervical spine that occurred over a 20-year period in an originally healthy cohort. We also sought to clarify the relationship between the progression of cervical degenerative changes and the development of clinical symptoms. For this prospective follow-up investigation, we recruited 193 subjects from an original cohort of 497 participants who had undergone magnetic resonance imaging (MRI) of the cervical spine between 1993 and 1996. The subjects were asked about the presence or absence of cervical spine-related symptoms. Degenerative changes of the cervical spine were assessed on MRI using an original numerical grading system. The relationship between the progression of degenerative changes and the onset of clinical symptoms was evaluated by logistic regression analysis. Degeneration in the cervical spine was found to have progressed in 95% of the subjects during the 20-year period. The finding of a decrease in signal intensity of the intervertebral disc progressed in a relatively high proportion of the subjects in all age groups and occurred with similar frequenc...Continue Reading

References

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Citations

Aug 14, 2018·Clinical Spine Surgery : a Spine Publication·Eijiro OkadaKota Watanabe
Oct 8, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Youping TaoHans-Joachim Wilke
Aug 26, 2020·The Journal of Bone and Joint Surgery. American Volume·Anne E H BroekemaJos M A Kuijlen
Apr 21, 2021·Aerospace Medicine and Human Performance·Richard E VailMarousa Pavlou

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