A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Graves' Hyperthyroidism and Graves' Orbitopathy

European Thyroid Journal
Roberto NegroKristian H Winther

Abstract

Selenium (Se) supplementation has been suggested in the treatment of Graves' disease (GD). We sought to investigate Se prescription patterns for GD across European countries. Members of the European Thyroid Association were invited to participate in an online survey investigating the use of Se in GD either without or with orbitopathy (GO). Of 872 invited members, 244 (28%) completed the survey. After exclusion of basic scientists and non-European members, 197 responses were retrieved out of clinical trials (nearly half of clinician members), of whom 61 do not use Se. Thus, 136 respondents remained for further analyses. Among the 136 analyzed respondents, most (64.7%) were not aware of the Se status in their populations, did not assess Se levels (78.7%), nor considered iodine status (74.3%). In GD without GO, 38.2% recommend Se supplementation ("sometimes" [27.2%], "frequently" [5.9%] or "always" [5.1%]). When GO occurs, 94.1% recommend Se supplementation ("sometimes" [39%], "frequently" [30.1%] or "always" [25%]). Of these, 60.1% recommend Se as an alternative to watchful waiting in patients with mild ocular involvement and 44.9% as an adjuvant to the established treatment modalities in patients with moderate to severe ocular i...Continue Reading

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Citations

Nov 14, 2019·Hormones : International Journal of Endocrinology and Metabolism·Tomasz Bednarczuk, Lutz Schomburg
Feb 1, 2020·Nature Reviews. Endocrinology·Kristian Hillert WintherLaszlo Hegedüs
Jan 22, 2020·Hormones : International Journal of Endocrinology and Metabolism·Monica Livia Gheorghiu, Corin Badiu
Apr 8, 2020·European Thyroid Journal·Kristian Hillert WintherLaszlo Hegedüs
Sep 10, 2020·European Thyroid Journal·Laszlo HegedüsEnrico Papini

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