PMID: 9422181Mar 1, 1995Paper

A 2,4-dichlorophenoxyacetic acid induced fatality

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
P G JorensP J Schepens

Abstract

This paper reports on a fatal intoxication by oral ingestion of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). At admission, the victim was unconscious. His condition deteroriated rapidly with blood loss from his mouth and nose. Since the cause of this condition was not known, gastroscopy was performed and haemorrhagic mucosa was observed in the mouth, oesophagus and stomach. Gastric contents (removed by lavage), urine and blood were submitted for toxicological analysis. Unfortunately, within 3 h of admission (about 5 h following ingestion of the toxin) profound cardiogenic shock developed and the patient died. The identity of the toxic xenobiotic was revealed by gas chromatography-mass spectrometry. Analytical quantification of the herbicide was performed by acid extraction prior to gas chromatographic examination using electron capture detection. His blood level of 2,4-D was 192 mg l-1.

Citations

Dec 8, 2004·Toxicological Reviews·Sally M BradberryJ Allister Vale
Apr 25, 2000·Journal of Toxicology. Clinical Toxicology·S M BradberryJ A Vale
Jul 18, 2018·Tropical Doctor·Ashok Kumar PannuNavneet Sharma
Jan 28, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Vaneet JearthKailashnath Sharma

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