A 25-year analysis of veterans treated for tonsillar squamous cell carcinoma

Archives of Otolaryngology--head & Neck Surgery
James J JaberCarol M Bier-Laning

Abstract

To determine the recurrence and survival outcome based on treatment date, type of treatment, stage of disease, and comorbidity and the recurrence and survival differences based on smoking status as a surrogate for human papillomavirus status in veterans treated for tonsillar squamous cell carcinoma (SCC). Outcome cohort study. Tertiary care Department of Veterans Affairs hospital. A consecutive sample from 1981 through 2006 of 683 patients treated for oropharyngeal SCC was screened, and 141 patients with tonsillar SCC without distant metastatic spread and a minimum of 2 years of follow-up were included. Disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS). Disease-free survival was significantly better in cohort II (treated during or after 1997) compared with cohort I (treated before 1997) (2- and 5-year DFS, 82% vs 64% and 67% vs 48%; P = .02). Disease-specific survival was better in the surgical vs nonsurgical group (2- and 5-year DSS, 77% vs 46% and 67% vs 30%; P < .001), as was the OS (2- and 5-year OS, 66% vs 41% and 45% vs 23%; P = .005). In subjects with early-stage disease, OS and DSS were not different regardless of treatment type. In subjects with late-stage disease treated most rece...Continue Reading

Citations

Mar 31, 2011·Infectious Agents and Cancer·Giuseppe PannonePantaleo Bufo
Jul 10, 2013·Korean Journal of Pathology·Dong Jin LeeSeong Jin Cho
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mia E MillerMaie St John
Sep 10, 2010·Nursing·Linda Schiech

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