A 2D finite element model of the interventricular septum under normal and abnormal loading

Computer Methods in Biomechanics and Biomedical Engineering
G S NelsonNigel G Shrive

Abstract

The interventricular septum is the structure that separates the left and right ventricles of the heart. Under normal loading conditions, it is concave to the left ventricle, but under abnormal loading the septum flattens and occasionally inverts. In the past, the septum has frequently been modelled as integral to the left ventricle with the effects of pressure from the right ventricle being ignored. Under abnormal loading, the septum has been described as behaving equivalent to a "flapping sail". There has been no consideration of structural behaviour under these conditions. A 2-D plane stress FE model of the septum was used to investigate the difference in structural behaviour of the septum during diastole between normal and abnormal loading. The biaxial stress patterns that develop are distinctively disparate. Under normal loading, the septum behaves much like a thick-walled cylinder subject to internal and external pressure, with the resulting stresses being circumferential tension and radial compression, both varying with radius. These stresses are very low throughout most of diastole. However, under abnormal loading, the septum behaves in an arch-like fashion, with high compressive stresses almost circumferential in direct...Continue Reading

References

Sep 1, 1976·Annals of Biomedical Engineering·Y C PaoE L Ritman
Jul 1, 1976·IEEE Transactions on Bio-medical Engineering·K R Brennen
Aug 1, 1992·The Journal of Physiology·P P de Tombe, H E ter Keurs
Feb 1, 1991·Journal of Biomechanical Engineering·J M GuccioneL K Waldman
Oct 1, 1990·Circulation Research·J WatanabeW Grossman
Sep 1, 1986·Circulation·J A LimaJ L Weiss
Nov 1, 1974·Journal of Biomechanics·R F JanzA F Grimm
Apr 1, 1970·Biophysical Journal·D D StreeterE H Sonnenblick
Jun 1, 1970·The Bulletin of Mathematical Biophysics·I Mirsky
Feb 19, 1971·Biochemical and Biophysical Research Communications·B Alpert, R Banerjee
Oct 1, 1983·Journal of Biomedical Engineering·A L YettramD G Gibson
Oct 1, 1995·Journal of Biomechanics·J M GuccioneA D McCulloch
Oct 24, 1998·Progress in Biophysics and Molecular Biology·K May-Newman, A D McCulloch
Jun 22, 1999·Annals of Biomedical Engineering·J RijckenT Arts
Aug 1, 1963·Circulation Research·H SANDLER, H T DODGE

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Citations

Jan 20, 2015·European Journal of Heart Failure·Thomas M GorterJoost P van Melle
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Carol A Gibbons KroekerNigel G Shrive
Jan 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Carol A Gibbons KroekerJohn V Tyberg
Sep 13, 2005·Computer Methods in Biomechanics and Biomedical Engineering·Jaroslav Mackerle

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