A 3-D constitutive model for finite element analyses of agarose with a range of gel concentrations.

Journal of the Mechanical Behavior of Biomedical Materials
Xiaogang WangDavid M Pierce

Abstract

Hydrogels have seen widespread application across biomedical sciences and there is considerable interest in using hydrogels, including agarose, for creating in vitro three-dimensional environments to grow cells and study mechanobiology and mechanotransduction. Recent advances in the preparation of agarose gels enable successful encapsulation of viable cells at gel concentrations as high as 5%. Agarose with a range of gel concentrations can thus serve as an experimental model mimicking changes in the 3-D microenvironment of cells during disease progression and can facilitate experiments aimed at probing the corresponding mechanobiology, e.g. the evolving mechanobiology of chondrocytes during the progression of osteoarthritis. Importantly, whether stresses (forces) or strains (displacements) drive mechanobiology and mechanotransduction is currently unknown. We can use experiments to quantify mechanical properties of hydrogels, and imaging to estimate microstructure and even strains; however, only computational models can estimate intra-gel stresses in cell-seeded agarose constructs because the required in vitro experiments are currently impossible. Finite element modeling is well-established for (computational) mechanical analyse...Continue Reading

References

Feb 18, 2004·Annals of Biomedical Engineering·Clark T HungGerard A Ateshian
Apr 10, 2012·Journal of Biomechanical Engineering·Steve A MaasJeffrey A Weiss
May 9, 2012·Annals of Biomedical Engineering·Spencer P LakeVictor H Barocas
Aug 16, 2013·Computer Methods in Biomechanics and Biomedical Engineering·C Bandeiras, A Completo
Oct 13, 2016·Expert Opinion on Drug Delivery·Lisa ElviriRuggero Bettini
May 6, 2017·Science·Yu Shrike Zhang, Ali Khademhosseini
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·D Caccavo, G Lamberti
Oct 8, 2017·Journal of Biomechanics·Carley N McCutchenRonald K June
Jul 22, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Xiaogang WangDavid M Pierce
Jul 10, 2019·Advanced Materials·Haitao LiuJianhua Qin

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