A 3-day exposure to 10% ethanol with 10% sucrose successfully initiates ethanol self-administration.

Alcohol
Jennifer CarrilloRueben A Gonzales

Abstract

The initiation phase of ethanol self-administration is difficult to study using the well-established, sucrose-fading procedure due to the changing concentrations of ethanol in the first few days. The purpose of this experiment was to test whether a modified sucrose-substitution procedure in which rats are initially exposed to high concentrations of ethanol and sucrose for three days would successfully initiate ethanol self-administration. Male Long-Evans rats were trained to lever-press with a 10% sucrose solution in which four or 20 responses allowed 20-min access to the solution. Subsequently, rats were exposed to a 3-day period of operant self-administration of 10% sucrose+10% ethanol. This constant-concentration exposure was followed by the standard procedure in which sucrose is completely faded out. The establishment of ethanol self-administration was determined by ethanol intake, pre- and postprocedure two-bottle choice preference tests, and extinction trials. The mean ethanol intake was 2.2 times higher on day 2 compared with day 1 on the 10% sucrose+10% ethanol solution. After fading out the sucrose, the daily intake of 10% ethanol solution over 5 days was stable at approximately 0.57 g/kg. Ethanol preference was approx...Continue Reading

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Citations

Mar 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey A SimmsSelena E Bartlett
Jul 21, 2009·Genes, Brain, and Behavior·J LeeS L McIntire
Aug 8, 2012·PloS One·Regina A MangieriRueben A Gonzales
Mar 19, 2014·Pharmacology, Biochemistry, and Behavior·Christian BrabantEtienne Quertemont
Aug 25, 2009·Pharmacology, Biochemistry, and Behavior·Jerry P PianCindy L Ehlers
Feb 24, 2015·Alcoholism, Clinical and Experimental Research·James M Doherty, Rueben A Gonzales
Mar 26, 2015·Frontiers in Pharmacology·Ana WeilandLori A Knackstedt
Mar 19, 2015·Frontiers in Behavioral Neuroscience·Chandra S SreyNadia Chaudhri
Sep 23, 2016·The Journal of Experimental Biology·Brian V EntlerMarc A Seid
May 31, 2020·Alcoholism, Clinical and Experimental Research·Elizabeth A SneddonAnna K Radke
Nov 12, 2019·Journal of the Experimental Analysis of Behavior·Leslie E SawyerKayce M Hopper

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