A 3-month preclinical trial to assess the performance of a new TVT-like mesh (TVTx) in a sheep model.

International Urogynecology Journal and Pelvic Floor Dysfunction
Masoumeh RezapourWalter Artibani

Abstract

The objective of this study was to evaluate in a sheep model the performance of a new polypropylene mesh (TVTx), which is intended as a less invasive treatment for female stress urinary incontinence. Eight female sheep were used in this study, each one being implanted with eight TVTx samples. At each time-point (weeks 1, 2, 4, and 12) seven TVTx were pulled out, while one TVTx was carefully dissected for histological investigations. One TVTx and one TVT, moreover, were inserted and immediately pulled out for obtaining the initial pullout forces in all sheep. The initial pullout values of TVT and TVTx were overlapping. The pullout forces of TVTx were >5 N (500 g) and increasing from weeks 1 to 12 (p<0.001). Histology revealed good tissue integration of TVTx in the tissue within 12 weeks after implantation. No abnormal histological findings were observed. This data could support the realization of a clinical trial with the TVTx mesh.

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Citations

Aug 27, 2009·The Journal of Obstetrics and Gynaecology Research·Hannah Krause, Judith Goh
Sep 4, 2015·Orphanet Journal of Rare Diseases·Ashish R PinnapureddyMichael R Eccles
Sep 18, 2007·International Urogynecology Journal and Pelvic Floor Dysfunction·M BoukerrouM Cosson
Nov 28, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Michele MeschiaLorenzo Spreafico
Feb 14, 2009·International Urogynecology Journal and Pelvic Floor Dysfunction·Petr HubkaJana Zvarova
Feb 27, 2010·International Urogynecology Journal·Salil KhandwalaDavid Sengstock
Apr 2, 2010·International Urogynecology Journal·Ladislav KroftaMichal Krcmár
Aug 28, 2010·International Urogynecology Journal·Petr HubkaJaromir Masata
Sep 3, 2011·International Urogynecology Journal·Francesco BernasconiMauro Cervigni
Jun 19, 2012·Expert Review of Obstetrics & Gynecology·Bruna M CouriMargot S Damaser
Aug 28, 2010·International Urogynecology Journal·Michele MeschiaLorenzo Spreafico
Feb 23, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Francesco AracoEmilio Piccione
Sep 22, 2007·Current Opinion in Obstetrics & Gynecology

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