PMID: 9638380Jun 25, 1998Paper

A 3-year audit of thyroid fine needle aspirates

Cytopathology : Official Journal of the British Society for Clinical Cytology
T F LioeR A Spence

Abstract

Fine needle aspiration (FNA) cytology is an important adjunct to the preoperative management of thyroid swellings. It is a simple and highly cost effective procedure with a higher sensitivity for the detection of malignancy than ultrasound and radio-isotope scans. We audited a total of 208 aspirates performed over a 3-year period. In our experience 61% of solitary thyroid swellings can be diagnosed confidently on FNA cytology as either non-neoplastic (46%) or neoplastic (15%). Based on these two groups the sensitivity is 91% and specificity 94%. The specificity, however, decreases to 40% if the group reactive vs neoplastic, which comprises 10-15% of cases and requires surgical intervention, is included. The positive predictive value for malignant disease is 94% while the false-negative and -positive rates excluding the unsatisfactory and reactive vs neoplastic groups are low at 2.7% and 5.4%, respectively (involving non-neoplastic lesions and benign tumours only). There was no case of malignant cytology with a benign biopsy follow up.

Citations

Mar 25, 2011·European Annals of Otorhinolaryngology, Head and Neck Diseases·M SellamiG Besbes
Aug 9, 2001·International Journal of Surgical Pathology·Lisa A. Cerilli, Mark R. Wick
Mar 5, 2021·Annals of Medicine and Surgery·Ahlem BchirMoncef Mokni

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