A 3D Model of the Effect of Tortuosity and Constrictivity on the Diffusion in Mineralized Collagen Fibril

Scientific Reports
Fabiano BiniFranco Marinozzi

Abstract

Bone tissue is a hierarchically structured material composed at the nanoscale by an organic matrix of collagen type I, apatite mineral and water. We considered an idealized 3D geometrical model of the mineralized collagen fibril in order to analyze the influence of structural factors, i.e. tortuosity, constrictivity, on the water effective diffusivity. The average values of the factors investigated in the diffusivity are computed on 5000 iterations by means of the Montecarlo method. The input parameters of the numerical model are the geometrical dimensions of the apatite mineral, collagen fibrils and their spatial orientation obtained with random extractions from Gaussian probability distribution functions. We analyzed the diffusion phenomenon for concentration gradients parallel to three orthogonal directions (Length, Width and Thickness) and for different scenarios, namely low, intermediate and high apatite volume fraction. For each degree of volume fraction, in the thickness direction, the tortuosity assumes greater values, up to two orders of magnitude, in comparison with the tortuous factors computed in the other directions, highlighting the anisotropy of the nanostructure. Furthermore, it was found that the tortuosity is ...Continue Reading

References

Nov 5, 2002·Journal of Biomechanics·Fabiano BiniFederico Patanè
Dec 18, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·William J Landis, Frederick H Silver
May 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·J A PETRUSKA, A J HODGE
Jun 23, 2004·Bone·Tue HassenkamPaul K Hansma
Jul 6, 2004·Journal of Theoretical Biology·Vincent LemaireLarry J Suva
Jun 30, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yu San WuKees van der Voort Maarschalk
Dec 22, 2007·Bone·P RoschgerK Klaushofer
Oct 15, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Maciej MatykaZbigniew Koza
Jun 4, 2010·Biomechanics and Modeling in Mechanobiology·Fang YuanL Catherine Brinson
Dec 15, 2010·Journal of Biomechanics·Franco MarinozziAndrea Marinozzi
Mar 30, 2012·Annali Dell'Istituto Superiore Di Sanità·Franco MarinozziRossella Bedini
Sep 28, 2013·Annali Dell'Istituto Superiore Di Sanità·Franco MarinozziRossella Bedini
Nov 7, 2013·Nature Materials·Yan WangNadine Nassif
Jan 15, 2014·BoneKEy Reports·Ming Fang, Mark M Banaszak Holl
Feb 21, 2014·Biomatter·Franco MarinozziAndrea Marinozzi
Apr 5, 2014·Nature Communications·Eliodoro ChiavazzoPaolo Decuzzi
Aug 27, 2014·Connective Tissue Research·Marta AidoWolfgang Wagermaier
Dec 17, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Ana Vercher-MartínezF Javier Fuenmayor
Jun 24, 2016·Journal of the Royal Society, Interface·Marios GeorgiadisPhilipp Schneider
Dec 22, 2017·Annals of the New York Academy of Sciences·Adele L Boskey, Laurianne Imbert

❮ Previous
Next ❯

Citations

Jun 2, 2021·Scientific Reports·Fabiano BiniFranco Marinozzi
Jun 30, 2021·Journal of Biomechanics·Fabiano BiniFranco Marinozzi

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopic tomography
biosensors

Software Mentioned

Mathematica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.