A 3D-Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction

Advanced Science
Yasamin A JodatSu Ryon Shin

Abstract

Advances in biomanufacturing techniques have opened the doors to recapitulate human sensory organs such as the nose and ear in vitro with adequate levels of functionality. Such advancements have enabled simultaneous targeting of two challenges in engineered sensory organs, especially the nose: i) mechanically robust reconstruction of the nasal cartilage with high precision and ii) replication of the nose functionality: odor perception. Hybrid nasal organs can be equipped with remarkable capabilities such as augmented olfactory perception. Herein, a proof-of-concept for an odor-perceptive nose-like hybrid, which is composed of a mechanically robust cartilage-like construct and a biocompatible biosensing platform, is proposed. Specifically, 3D cartilage-like tissue constructs are created by multi-material 3D bioprinting using mechanically tunable chondrocyte-laden bioinks. In addition, by optimizing the composition of stiff and soft bioinks in macro-scale printed constructs, the competence of this system in providing improved viability and recapitulation of chondrocyte cell behavior in mechanically robust 3D constructs is demonstrated. Furthermore, the engineered cartilage-like tissue construct is integrated with an electrochemic...Continue Reading

References

Jan 1, 1986·Bioelectromagnetics·A P MazzoleniR L Kahler
Mar 25, 1999·Cell·B MalnicL B Buck
Sep 15, 2001·Nature·S Firestein
Jan 21, 2003·Archives of Facial Plastic Surgery·Mark R HomiczDeborah Watson
Sep 6, 2003·International Journal of Biological Macromolecules·Edith van den Bosch, Constant Gielens
Feb 26, 2004·The Journal of Laryngology and Otology·Michael WolfDavid Elad
Oct 21, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Steven E ChurchillMichael T Black
Dec 25, 2004·Anesthesiology·C William Hanson, Erica R Thaler
Oct 27, 2006·American Journal of Rhinology·Jeremy D RichmonDeborah Watston
Mar 6, 2009·Science Signaling·Harumi SaitoJoel D Mainland
Apr 27, 2010·Biomaterials·Jason W NicholAli Khademhosseini
Oct 15, 2010·Nano Letters·Yue CuiMichael C McAlpine
Dec 7, 2010·Progress in Neurobiology·Richard Glatz, Kelly Bailey-Hill
Feb 11, 2011·Tissue Engineering. Part a·Che B HutsonAli Khademhosseini
Dec 14, 2011·Biomaterials·Sang Hun LeeTai Hyun Park
Mar 8, 2012·Tissue Engineering. Part a·Xiaofeng CuiDarryl D D'Lima
Apr 6, 2012·Biosensors & Bioelectronics·Hye Jun JinSeunghun Hong
Jul 17, 2012·Osteoarthritis and Cartilage·M M J CaronT J M Welting
Aug 21, 2012·Biosensors & Bioelectronics·Jong Hyun LimTai Hyun Park
Jan 26, 2013·Journal of Tissue Engineering and Regenerative Medicine·Joydip KunduDong-Woo Cho
Apr 2, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Rihab SahliBenoît Limoges
Apr 30, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Jonas GruberMárcia A Shirakawa
May 3, 2013·Nano Letters·Manu S MannoorMichael C McAlpine
Jul 23, 2013·Advanced Healthcare Materials·Jong Hyun LimTai Hyun Park
Apr 25, 2015·Biosensors & Bioelectronics·Seung Hwan LeeTai Hyun Park
Jun 19, 2015·Nature·Vivien Marx
Jul 21, 2015·Advanced Energy Materials·Paolo BombelliTuomas P J Knowles
Nov 19, 2015·ACS Nano·William J PevelerIvan P Parkin
Feb 20, 2016·Angewandte Chemie·Falguni PatiHelene Andersson Svahn
May 18, 2016·Annals of Biomedical Engineering·David ChimeneAkhilesh K Gaharwar
Aug 20, 2016·ACS Applied Materials & Interfaces·Juhan LeeVolker Presser
Sep 25, 2016·Biosensors & Bioelectronics·Manki SonTai Hyun Park

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Citations

Jul 23, 2020·Frontiers in Physiology·Lauren RichardsonArum Han
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tarun AgarwalTapas Kumar Maiti
Apr 13, 2021·Frontiers in Cell and Developmental Biology·Jianjun LiSha Huang
Apr 18, 2021·Tissue Engineering and Regenerative Medicine·Carlos M Chiesa-EstombaAnder Izeta
May 25, 2021·Essays in Biochemistry·Anisha KabirIbrahim T Ozbolat
Jul 2, 2021·International Journal of Biological Macromolecules·Jing-Han WangYi-Chen Ethan Li
Jul 28, 2021·Aesthetic Plastic Surgery·Yanyan CaoYonghuan Zhen

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Methods Mentioned

BETA
biosensor
bioprinting
biosensors
biosensing
scanning electron microscopy
Fluorescence imaging
quantum dot array
bioprinter

Software Mentioned

Graphpad Prism
Slic3r
code

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