A 3D two-point method for whole-brain water content and relaxation time mapping: Comparison with gold standard methods

PloS One
Melissa SchallAna-Maria Oros-Peusquens

Abstract

Quantitative imaging of the human brain is of great interest in clinical research as it enables the identification of a range of MR biomarkers useful in diagnosis, treatment and prognosis of a wide spectrum of diseases. Here, a 3D two-point method for water content and relaxation time mapping is presented and compared to established gold standard methods. The method determines free water content, H2O, and the longitudinal relaxation time, T1, quantitatively from a two-point fit to the signal equation including corrections of the transmit and receive fields. In addition, the effective transverse relaxation time, T2*, is obtained from an exponential fit to the multi-echo signal train and its influence on H2O values is corrected. The phantom results obtained with the proposed method show good agreement for H2O and T1 values with known and spectroscopically measured values, respectively. The method is compared in vivo to already established gold standard quantitative methods. For H2O and T2* mapping, the 3D two-point results were compared to a measurement conducted with a multiple-echo GRE with long TR and T1 is compared to results from a Look-Locker method, TAPIR. In vivo results show good overall agreement between the methods, bu...Continue Reading

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Citations

Jun 1, 2019·Journal of Magnetic Resonance Imaging : JMRI·Melissa SchallN Jon Shah

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Methods Mentioned

BETA
nuclear magnetic resonance

Software Mentioned

in
house
GRAPPA
TAPIR
SPM
SPM12
DESPOT

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