A 4-midable Connection: CCR7 Tetramers Link GPCR to Src Kinase Signaling

Immunity
Reinhold FörsterKathrin Werth

Abstract

Chemokine receptors are known to signal through heterotrimeric G proteins. In this issue, Hauser et al. (2016) report that inflammatory cues can induce tetramers of the chemokine receptor CCR7 that serve as scaffolds integrating G protein with Src kinase signaling.

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