PMID: 8588686Jul 1, 1995Paper

A 4-week comparison of salmeterol and terbutaline in adult asthma

Allergy
B A Hermansson, R J Jenkins

Abstract

This was a 4-week, open-label, parallel-group study designed to compare the efficacy and safety of the long-acting inhaled bronchodilator, salmeterol, with the established inhaled bronchodilator, terbutaline, in the treatment of patients with mild to moderate asthma. A total of 243 adult patients was randomized to receive treatment with either salmeterol 50 micrograms bd via a Diskhaler (Glaxo) inhaler (n = 121) or terbutaline 500 micrograms qds via a reservoir powder inhaler device (n = 122). Apart from all bronchodilator treatment which was withdrawn at the start of the run-in period and replaced by inhaled salbutamol to be used as required for symptom relief, all concurrent medications were kept constant throughout the study. Salmeterol produced a significantly greater increase in mean morning peak expiratory flow (PEF) than terbutaline (difference in adjusted means after treatment = 28 l/min; 95% CI = 19-37 l/min; P < 0.001). Likewise, the increase in mean evening PEF was significantly greater following treatment with salmeterol than with terbutaline (difference in adjusted means = 9 l/min; 95% CI = 0-17 l/min; P = 0.045). Salmeterol was associated with a significant reduction in diurnal variation in PEF by comparison with ...Continue Reading

References

Feb 20, 1992·The New England Journal of Medicine·W O SpitzerA S Rebuck
Jan 1, 1992·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·B J Lipworth
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R A Nathan
Nov 12, 1992·The New England Journal of Medicine·D S PearlmanS W Yancey
Jan 1, 1992·European Journal of Clinical Pharmacology·D NowakH Magnussen
Apr 13, 1991·Lancet·M M JenkinsJ B Palmer
Jan 1, 1990·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J P Kemp, E O Meltzer
Dec 8, 1990·Lancet·M R SearsG P Herbison
Jan 1, 1986·Current Medical Research and Opinion·K B BeswickS Sampson
Jun 4, 1994·Lancet·K R ChapmanJ P Szalai
Jan 1, 1993·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S S Nasser, P J Rees

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Citations

Apr 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A F KalyoncuY I Bariş
Aug 24, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A CarroccioG Iacono
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E KivisaariM J Price
Feb 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·D H Richards, C M Milton
Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·N Mygind, R Dahl
Apr 29, 1998·Chest·R H MooreB F Dickey
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Christopher J Cates, Matthew J Cates
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Hanneke J van der Woude, René Aalbers

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