A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits

Physiology & Behavior
K J SimanskyAnthony G Romano

Abstract

Serotonergic 5-HT2C and 5-HT1B receptors mediate inhibitory controls of eating. Questions have arisen about potential behavioral and neurological toxicity of drugs that stimulate the 2C site. We evaluated eating and other motor responses in male Dutch-belted rabbits after administration of m-chlorophenylpiperazine (mCPP). Studies conducted in vitro and in vivo assessed the pharmacological specificity of the ingestive actions of this agent. mCPP (0.15-10 micromol/kg sc) reduced consumption of chow and 20% sucrose solution with equal potencies (ED50 approximately equal 0.6 micromol/kg). In radioligand binding to rabbit cortex, mCPP displayed 15-fold higher affinity for 5-HT2C than for 5-HT1B receptors. The serotonin antagonist mesulergine (7000-fold selective for 5-HT2C) reversed the hypophagic action of mCPP, but the 5-HT1B/1D antagonist GR127,935 did not. GR127,935 (0.5 micromol/kg) did prevent hypophagia produced by the highly selective 5-HT1B/1D agonist GR46,611. Observational methods demonstrated that mCPP decreased the frequency of eating chow but increased other motor activities. When rabbits consumed sucrose, videoanalysis revealed that mCPP reduced total time licking and the duration of individual bouts, but not bout fre...Continue Reading

References

Sep 1, 1994·Psychopharmacology·A E WalshP J Cowen
Aug 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·T D BrewertonD C Jimerson
May 1, 1996·Neuroscience·K Eberle-WangM F Chesselet
Jun 1, 1997·Psychopharmacology·M D Lee, K J Simansky
Nov 15, 1997·Psychopharmacology·P A SargentP J Cowen
Aug 15, 1998·Psychiatry Research·T KlaassenH M van Praag
May 14, 1999·European Journal of Pharmacology·M F O'Neill, G J Sanger
Jan 16, 2002·Physiology & Behavior·J A BouwknechtB Olivier
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Kuldip D DaveVincent J Aloyo
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rudy Schreiber, Jean De Vry
Apr 8, 2003·Current Topics in Medicinal Chemistry·Michael J Bickerdike
Jun 27, 2003·Journal of Medicinal Chemistry·Richard A Glennon
Jan 1, 1994·Journal of Psychopharmacology·M SkingleW Feniuk

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Citations

Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Regis ParmentierOlga A Sergeeva
Dec 1, 2015·Pharmacology & Therapeutics·Giuseppe Di Giovanni, Philippe De Deurwaerdère
Mar 24, 2006·The European Journal of Neuroscience·Heather G WardKenny J Simansky
Apr 26, 2012·The International Journal of Eating Disorders·Guido K W Frank, Walter H Kaye
Feb 22, 2012·Neuropsychologia·Charlotte KeatingPaul B Fitzgerald
Jul 16, 2009·Nature Reviews. Neuroscience·Walter H KayeMartin Paulus
Jan 1, 2005·International Journal of Psychiatry in Clinical Practice·Eric Hollander
Jul 28, 2009·Behavioural Brain Research·Luciane Coutinho Azevedo CampanellaJosé Marino-Neto

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