PMID: 8938255Feb 9, 1996Paper

A 5-hydroxytryptamine lesion markedly reduces the incidence of burst-firing dorsal raphe neurones in the rat

Neuroscience Letters
Mihály Hajós, Trevor Sharp

Abstract

Recently, we described neurones in the rat dorsal raphe nucleus (DRN) with electrophysiological characteristics typical of 5-hydroxytryptamine (5-HT) neurones except that the neurones fired brief bursts. Here we report the effect of 5-HT lesions on the incidence of these burst-firing neurones. In vivo extracellular recordings revealed that in rats pretreated with the selective 5-HT neurotoxin, 5,7-dihydroxytryptamine, the occurrence of typical 5-HT neurones was significantly decreased (80%) compared to controls. In these 5-HT lesioned animals, the number of the burst-firing DRN neurones was also significantly reduced (91%). Neurones previously characterised as not containing 5-HT, were not altered by the lesion. These data are further evidence to support our hypothesis that burst-firing neurones in the DRN contain 5-HT.

References


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Citations

Oct 19, 2002·Pathophysiology : the Official Journal of the International Society for Pathophysiology·H AlaeiA Rafati
Jun 7, 2011·Journal of Chemical Neuroanatomy·Rani K VasudevaBarry D Waterhouse
Sep 3, 2008·Journal of Neurochemistry·Sarah ThrelfellSusan A Greenfield
Aug 19, 2016·Frontiers in Cellular Neuroscience·Boris MlinarRenato Corradetti

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