A 5'-upstream short open reading frame encoded peptide regulates angiotensin type 1a receptor production and signalling via the β-arrestin pathway

The Journal of Physiology
Gina L C YostenWillis K Samson

Abstract

AUG sequences and short open reading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs. The presence of these upstream AUG sequences has been demonstrated to inhibit downstream receptor translation efficiency and, most recently, receptor signal transduction. A seven amino acid peptide encoded by a short open reading frame in exon 2 of the angiotensin type 1a receptor has been shown to inhibit non-G protein-coupled signalling of angiotensin II, without altering the classical G protein-coupled pathway activated by the ligand. This finding may lead to the development of a new class of angiotensin receptor antagonists with activities biased for one, but not all, of the signalling cascades activated by angiotensin II, which could have therapeutic implications for the myriad hormones and neurotransmitters that signal through G protein-coupled receptors.

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Citations

Nov 19, 2015·Nucleic Acids Research·Hélène MouilleronXavier Roucou
Mar 21, 2016·The Journal of Physiology·Julian F R Paton
Aug 21, 2020·Experimental Cell Research·Peter F RenzAtaman Sendoel
Dec 1, 2017·Journal of Proteome Research·Anastasia ChugunovaPetr Sergiev
Jul 10, 2021·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Diego Guerra-AlmeidaRodrigo Nunes-da-Fonseca

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