PMID: 9551876Apr 29, 1998Paper

A 5-year comparison of doxazosin and atenolol in patients with mild-to-moderate hypertension: effects on blood pressure, serum lipids, and coronary heart disease risk

Blood Pressure
L N Daae, L Westlie

Abstract

The long-term efficacy and safety of once-daily treatment with doxazosin or atenolol were compared in a 5-year study in patients with mild-to-moderate hypertension. The study consisted of a 1-year, multicenter, double-blind, parallel-group phase, followed by a 4-year, open-label extension phase. Of the 228 patients enrolled, 100 patients (54/111 doxazosin and 46/117 atenolol) completed the 5-year study. Both treatments were similarly efficacious in controlling blood pressure. As assessed by the Framingham risk equation, which incorporates lipid parameter values, patients receiving doxazosin had significantly less chance of developing coronary heart disease (CHD) within 10 years compared with those patients receiving atenolol (p < 0.05). Doxazosin significantly (p=0.0005) reduced the mean CHD risk from baseline to final visit by 12.3%; whereas, atenolol produced essentially no change in mean risk (0.2% increase). In patients receiving doxazosin, statistically significant (p < 0.05) increases from baseline were observed in serum concentrations of high-density lipoprotein (HDL) cholesterol and the HDL/total cholesterol ratio during the first 2 and 3 years of treatment, respectively. In contrast, significant (p < 0.05) percent redu...Continue Reading

Citations

Feb 20, 2007·Postgraduate Medical Journal·Stephen S Connolly, John M Fitzpatrick
Nov 26, 1999·Clinical and Experimental Hypertension : CHE·T LittlejohnT Marbury
Jan 14, 2010·Current Medical Research and Opinion·Vivian A Fonseca
Dec 7, 2005·The Journal of Clinical Hypertension·Domenic A Sica
Apr 30, 2005·International Journal of Cardiology·Carlos CalvoBeatriz Armada
Mar 30, 2016·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Pyung Chun OhEak Kyun Shin
Jun 5, 2002·The Journal of Clinical Hypertension·D A Sica
Jun 20, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Paul Ernsberger, Richard J Koletsky
Jul 27, 2001·Current Hypertension Reports·D Sica
May 28, 2019·The Proceedings of the Nutrition Society·Andrew M Salter
Mar 30, 2017·Current Hypertension Reports·Hamish Cg ProsserMarkus P Schlaich

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