A 5-Year Longitudinal Clinical and Magnetic Resonance Imaging Study in Spinocerebellar Ataxia Type 3.

Movement Disorders : Official Journal of the Movement Disorder Society
Camila Callegari PiccininMarcondes Cavalcante França

Abstract

The natural history of neurodegeneration in spinocerebellar ataxia type 3/Machado Joseph disease is still unclear. Here, we built a long-term longitudinal clinical and neuroimaging study to address this point. Twenty-three patients with spinocerebellar ataxia type 3/Machado Joseph disease and 22 healthy controls underwent 3T MRI twice 5.0 years apart. T1 and diffusion tensor imaging sequences were obtained. We used T1 multiatlas, diffusion tensor imaging multiatlas, SpineSeg, and CERES-SUIT for cerebral gray and white matter, spinal cord and cerebellar analyses, respectively. Clinical severity was assessed with scale for assessment and rating of ataxia. Analysis of covariance evaluated longitudinal between-group changes. Effect sizes were calculated for each significant result. Progressive volumetric abnormalities were most evident in the cerebellum (Lobule X and Crus II; effect size, 2.0), followed by the basal ganglia (effect size, 0.7). The cerebellar peduncles had the largest white-matter diffusivity changes (effect size, 1.29). Scale for assessment and rating of ataxia-related effect size was 0.82. We failed to identify progressive spinal cord abnormalities. Longitudinal changes in spinocerebellar ataxia type 3/Machado Jos...Continue Reading

References

Jun 14, 2006·Neurology·T Schmitz-HübschRoberto Fancellu
May 22, 2009·NeuroImage·Jörn DiedrichsenNarender Ramnani
Oct 9, 2009·Parkinsonism & Related Disorders·Anelyssa D'AbreuIscia Lopes-Cendes
Feb 24, 2010·Neurology·T Schmitz-HübschT Klockgether
Jun 28, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Anelyssa D'AbreuFernando Cendes
Feb 21, 2013·Brain : a Journal of Neurology·Kathrin ReetzUNKNOWN axia Study Group Investigators
Apr 5, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Rachel P GuimarãesFernando Cendes
Jan 19, 2016·Neurogenetics·Karina Carvalho DonisLaura Bannach Jardim
Jun 21, 2018·NeuroImage. Clinical·Isaac M AdanyeguhFanny Mochel
Jul 18, 2018·Annals of Neurology·Thiago Junqueira Ribeiro RezendeMarcondes C França
Sep 5, 2019·Brain and Behavior·Thiago J R RezendeAndreia V Faria

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Citations

Apr 28, 2020·The Cerebellum·Thomas IhlHanna G Zimmermann
Apr 10, 2021·Journal of the Neurological Sciences·Meng-Ling ChenSheng-Han Kuo
May 6, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer FaberThomas Klockgether

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