A 5-year longitudinal study of the relationships between stress, coping, and immune cell beta(2)-adrenergic receptor sensitivity.

Psychiatry Research
Brent T MausbachIgor Grant

Abstract

Caring for a spouse with Alzheimer's disease (AD) is associated with overall health decline and impaired cardiovascular functioning. This morbidity may be related to the effects of caregiving stress and impaired coping on beta(2)-adrenergic receptors, which mediate hemodynamic and vascular responses and are important for peripheral blood mononuclear cell (PBMC) trafficking and cytokine production. This study investigated the longitudinal relationship between stress, personal mastery, and beta(2)-adrenergic receptor sensitivity assessed in vitro on PBMC. Over a 5-year study, 115 spousal AD caregivers completed annual assessments of caregiving stress, mastery, and PBMC beta(2)-adrenergic receptor sensitivity, as assessed by in vitro isoproterenol stimulation. Heightened caregiving stress was associated with significantly decreased receptor sensitivity, whereas greater sense of personal mastery was associated with significantly increased receptor sensitivity. These results suggest that increased stress may be associated with a desensitization of beta(2)-receptors, which may contribute to the development of illness among caregivers. However, increased mastery is associated with increased receptor sensitivity, and may therefore serv...Continue Reading

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Citations

Feb 11, 2014·International Psychogeriatrics·Irina Fonareva, Barry S Oken
May 21, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jennifer S HoBrent T Mausbach
Feb 12, 2011·Current Psychiatry Reports·Alexandrea L HarmellBrent T Mausbach
May 4, 2011·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Susan K Roepke, Igor Grant
Aug 1, 2012·Cardiovascular Psychiatry and Neurology·Roland von KänelIgor Grant
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Apr 14, 2017·Cellular and Molecular Neurobiology·Petr NovakPeter Filipcik
Mar 27, 2019·Scientific Reports·Jose Pablo Miramontes-GonzalezDaniel T O'Connor

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