Nov 1, 1985

A 50 kilodalton exoantigen specific to the merozoite release-reinvasion stage of Plasmodium falciparum

Molecular and Biochemical Parasitology
P DelplaceA Vernes

Abstract

The immunoglobulins G of a human plasma inhibiting in vitro Plasmodium falciparum merozoite reinvasion have been purified and used to immunoprecipitate the antigens released into the culture medium by an [35S]methionine-labeled synchronous culture. Several of the major exoantigens identified were found throughout the entire life cycle; they were also immunoprecipitated from the labeled parasitized cells. Some antigens were found only after the reinvasion stage, and especially a major one of molecular mass 50 kDa and pI 5.5. The latter was not found in the parasitized cells but derived most likely from the processing of a major 126 kDa antigen which disappeared from the parasites during the reinvasion period and which was immunoprecipitated by an anti-50 kDa monoclonal antibody.

Mentioned in this Paper

Human plasma
Monoclonal Antibodies
Merozoites
SDS-PAGE
Antigens, Protozoan
Pedameth
Immunoglobulins
Malaria
Antigens
Immune complex

About this Paper

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