PMID: 6537941Jan 1, 1984Paper

A 6-month dietary toxicity study of acidic sodium aluminium phosphate in beagle dogs

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
A C KatzR I Freudenthal

Abstract

Sodium aluminium phosphate [NaAl3H14(PO4)8. 4H2O], a leavening acid, was administered to groups of six male and six female beagle dogs at dietary concentrations of 0, 0.3, 1.0 or 3.0% for 6 months. No adverse treatment-related clinical signs were observed. There were no statistically significant differences in mean body weights between test and control groups at any of the weekly determinations. Weekly mean food consumption values of all male treated groups did not differ significantly from those of the control group at any stage of the study. Statistically significant reductions in food consumption occurred sporadically in all treated groups of female dogs. No significant absolute or relative organ-weight differences were found between any of the treated groups and their respective controls. Haematological, blood chemistry and urinalysis data showed no toxicologically significant trends. Histopathological examination revealed no changes considered to be related to treatment. Thus dietary administration of sodium aluminum phosphate for 6 months at concentrations of 3% or lower caused no significant toxicological effects in beagle dogs.

Citations

Jul 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J S HicksG L Sprague
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Apr 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert A YokelRebecca L Florence
May 17, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mutsuko Hirata-KoizumiAkiyoshi Nishikawa
Nov 26, 2010·Reproductive Toxicology·Mutsuko Hirata-KoizumiAkiyoshi Nishikawa
Feb 10, 2012·Interdisciplinary Toxicology·Natália SedláčkováMojmír Mach
Apr 20, 2012·Critical Reviews in Toxicology·Calvin C WillhiteClifton J McLellan
Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel
Mar 25, 2020·Interdisciplinary Toxicology·Ikechukwu Onyebuchi IgbokweNanacha Afifi Igbokwe

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