A 6-month telephone-based weight loss intervention in overweight and obese subjects with idiopathic intracranial hypertension

Obesity Science & Practice
Richard WeilNORDIC Idiopathic Intracranial Hypertension Study Group

Abstract

The purpose of this paper is to measure the change in body weight after a 6-month telephone-based weight loss intervention in overweight and obese subjects with idiopathic intracranial hypertension (IIH) and mild visual loss randomized to receive either acetazolamide or placebo. One hundred sixty-five subjects with IIH, aged 29.1 ± 7.5 (mean ± SD) and BMI 39.9 + 8.3 kg/m2, enrolled at 38 academic and private practice sites in North America, participated in this trial. This was a randomized, double-masked, placebo-controlled trial of acetazolamide in subjects with IIH and mild visual loss. All participants received a reduced-sodium, weight-reduction diet and a 6-month telephone-based weight loss intervention. Six-month changes from baseline in body weight, perimetric mean deviation as assessed by automated perimetry and quality of life using the National Eye Institute Visual Function Questionnaire 25 and the 36-item Short Form Health Survey were measured. Mean percent weight change at 6 months was -5.9% ± 6.7% of initial body weight overall, -3.5% ± 5.9% in the placebo group and -7.8% ± 6.8% in the acetazolamide group. Weight change was not associated with changes in either mean deviation or quality of life scores. Patients with...Continue Reading

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Citations

Sep 8, 2018·Journal of Clinical Psychopharmacology·Anil KakunjeRekha Pd
Feb 9, 2018·Critical Reviews in Food Science and Nutrition·Sandra Ayisi Addo, Matilda Steiner-Asiedu
Feb 9, 2021·The Cochrane Database of Systematic Reviews·Thomas SemlitschAndrea Siebenhofer
Nov 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Juan Lyn AngClare L Fraser

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BETA
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