PMID: 11325075Apr 28, 2001Paper

A-6G variant of the angiotensinogen gene and essential hypertension in Han, Tibetan, and Yi populations

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Y LiuC Qiu

Abstract

To investigate the relationship between the A-6G variant in the promoter of the angiotensinogen gene and essential hypertension in Han, Tibetan, and Yi populations. All patients with essential hypertension were selected by WHO criteria. And the polymorphism of the A-6G variant was determined by PCR/RFLP. The data were analyzed by t test and chi2 test. There was no significant difference in the genotype or allele frequencies between normotensives and hypertensives in the Han, Tibetan, and Yi populations, respectively. However, when the subjects were divided into male and female subgroups, the genotype distributions among hypertensives and normotensives of the Tibetan female group were as follows: AA, 37% vs. 48%; AG, 52% vs. 48%; GG, 11% vs. 4%, respectively and the frequency of the G allele was significantly higher in hypertensives than in normotensives in the Tibetan female group (0.37 vs. 0.28, chi2=4.25, p<0.05). In addition, we observed that there was a significant difference between the Han and Tibetan normotensive groups in the distributions of the allele and genotype frequencies of the A-6G variant. The frequency of the G allele was 0.29 and 0.17 in the Tibetan normotensive and Han groups, respectively (p<0.001). The G a...Continue Reading

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Apr 1, 1999·Journal of Hypertension·J A StaessenR Fagard

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Citations

Oct 3, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ying LiuChangchun Qiu
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Luobu GesangYong Chan
Apr 2, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaru ShojiMinoru Yasujima
Jan 28, 2006·Clinical Chemistry·Hironobu SanadaRobin A Felder
Dec 14, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bo XiJie Mi
Nov 12, 2021·Experimental Biology and Medicine·Zongjin LiChengying Yan

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