A 9-Year Longitudinal Study of Basilar Artery Diameter

Journal of the American Heart Association
Mariko TakeuchiH Mochizuki

Abstract

Background Dilatation of the basilar artery ( BA ) has been recognized as a predictor of cardiovascular events ( CVE s). However, it is unclear if the longitudinal change in BA diameter (Δ BA ) is associated with CVE s. Methods and Results In a cohort of Japanese participants with vascular risk factors in an observational study, we evaluated the relationship of Δ BA to CVE s and the time course of the BA diameter. The short axis of the BA diameter was measured at the midpons level in T2-weighted images. Brain magnetic resonance imaging measurements included cerebral small-vessel disease, lacunars, and white matter hyperintensities. First, 493 patients were analyzed by the time-dependent Cox proportional hazards model to evaluate the association between Δ BA and CVE s, with adjustment for age, sex, vascular risk factors, and magnetic resonance imaging parameters. Second, we assessed the longitudinal Δ BA in 164 patients who underwent long-term follow-up magnetic resonance imaging, by linear regression analysis. In the mean follow-up of 8.7 years, 105 patients developed CVE s. A smaller Δ BA was independently associated with the high incidence of CVE s (hazard ratio, 0.36; 95% CI, 0.16-0.78; P=0.010; n=493). After a mean interval...Continue Reading

References

Dec 3, 1999·Stroke; a Journal of Cerebral Circulation·M J HartkampW P Mali
Dec 25, 2003·Neurology·Fernando PicoUNKNOWN GENIC Investigators
Mar 2, 2005·Annals of Neurology·Fernando PicoPierre Amarenco
Apr 30, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Hiroshi YamagamiMasatsugu Hori
Aug 5, 2006·Stroke; a Journal of Cerebral Circulation·Fernando PicoUNKNOWN GENIC Investigators
Feb 27, 2007·Stroke; a Journal of Cerebral Circulation·Fernando PicoPierre Amarenco
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
May 30, 2009·Stroke; a Journal of Cerebral Circulation·Edouard FonckNikolaos Stergiopulos
Sep 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroo IchikawaMitsuru Kawamura
Aug 11, 2012·Stroke; a Journal of Cerebral Circulation·Mariëlle M F PoelsM Arfan Ikram
Nov 24, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Kaori MiwaKazuo Kitagawa
May 11, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Makiko TanakaKazuo Kitagawa
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Aug 16, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Richard H Swartz
Aug 21, 2014·Stroke; a Journal of Cerebral Circulation·Shuhei OkazakiKazuo Kitagawa
Oct 31, 2015·Stroke; a Journal of Cerebral Circulation·Fernando PicoPierre Amarenco
Jan 9, 2016·Stroke; a Journal of Cerebral Circulation·Ye QiaoBruce A Wasserman
Jul 30, 2017·Stroke; a Journal of Cerebral Circulation·Vincent ThijsUNKNOWN Stroke in Fabry (SIFAP1) Investigators
Sep 14, 2017·European Neurology·Oscar H Del BruttoVictor J Del Brutto

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

JMP
IADE
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arteriosclerosis, Thrombosis, and Vascular Biology
Makiko TanakaK Kitagawa
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Hiroo IchikawaMitsuru Kawamura
Cephalalgia : an International Journal of Headache
Tal Eidlitz-MarkusOsnat Konen
© 2022 Meta ULC. All rights reserved