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A 90-day oral gavage toxicity study of D-methylphenidate and D,L-methylphenidate in Sprague-Dawley rats

Toxicology

Oct 15, 2002

Steve K TeoVikram D Khetani

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Abstract

D-methylphenidate is an enantiomer of D,L-methylphenidate and was developed as an improved treatment for attention deficit hyperactivity disorder in children. The current study was performed to determine and compare the toxicity of 2-50 mg/kg per day D-MPH and 100 mg/kg per day D,L-MPH ...read more

Mentioned in this Paper

Metadate
Methylphenidate
Weighing Patient
Enantiomer
Dose-Response Relationship, Drug
Nose
Scab
Metazoa
Attention Deficit Hyperactivity Disorder
Rats, Holtzman
55
Paper Details
References
  • References13
  • Citations72
12
  • References13
  • Citations72
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A 90-day oral gavage toxicity study of D-methylphenidate and D,L-methylphenidate in Sprague-Dawley rats

Toxicology

Oct 15, 2002

Steve K TeoVikram D Khetani

PMID: 12270592

DOI: 10.1016/s0300-483x(02)00338-4

Abstract

D-methylphenidate is an enantiomer of D,L-methylphenidate and was developed as an improved treatment for attention deficit hyperactivity disorder in children. The current study was performed to determine and compare the toxicity of 2-50 mg/kg per day D-MPH and 100 mg/kg per day D,L-MPH ...read more

Mentioned in this Paper

Metadate
Methylphenidate
Weighing Patient
Enantiomer
Dose-Response Relationship, Drug
55

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Paper Details
References
  • References13
  • Citations72
12
  • References13
  • Citations72
12345...

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