A 90-day oral toxicity study of nisin A, an anti-microbial peptide derived from Lactococcus lactis subsp. lactis, in F344 rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Akihiro HagiwaraShim-Mo Hayashi

Abstract

This study was designed to evaluate and characterize any adverse effect of nisin A, when administered to both sexes of F344/DuCrlCrlj rats (10 males and 10 females in each group) at dietary levels of 0%, 0.2%, 1.0% and 5.0% for 90 days. Animals given NaCl at a dietary level of 3.712% (equivalent to the NaCl content in 5.0% nisin A diet) served as a reference material treated group. There were no deaths, and the treatment had no toxicologically significant effects on clinical signs, body weights, food consumption, ophthalmology, hematology, or gross pathology. Statistically significant increases of water consumption, urine volume, and urinary sodium and chlorine, and decreases of urinary potassium and serum sodium, along with increases of absolute and relative kidney weight, and incidences of minimal squamous cell hyperplasia of limiting ridge in the forestomach, were found in nisin A-treated groups. It was considered that these changes were related to NaCl, since they were also noted in rats given diet containing the reference substance. Thus, no toxicologically significant changes were apparent in both sexes of F344/DuCrlCrlj rats fed diet containing 0%, 0.2%, 1.0% and 5.0% nisin A for 90 days. Therefore, the no-observed-adver...Continue Reading

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Citations

Feb 5, 2013·BMC Microbiology·Alicia CampionR Paul Ross
Feb 28, 2014·Future Microbiology·Timothy D ArthurMichael L Chikindas
Apr 28, 2011·Expert Opinion on Drug Metabolism & Toxicology·Auke Johan van HeelOscar P Kuipers
Oct 4, 2011·International Journal of Pharmaceutics·Rodrigo de Almeida VaucherAdriano Brandelli
Jul 3, 2018·Frontiers in Microbiology·Ronan GoughMary C Rea
Dec 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)David Gott
Jan 7, 2021·Probiotics and Antimicrobial Proteins·Haodan ZhuKongwang He
Dec 29, 2020·Peptides·Joanna Małaczewska, Edyta Kaczorek-Łukowska
Sep 3, 2020·FEMS Microbiology Reviews·Samira SoltaniIsmail Fliss
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Márcio CarochoIsabel C F R Ferreira

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