A 980 nm laser-activated upconverted persistent probe for NIR-to-NIR rechargeable in vivo bioimaging

Nanoscale
Zhenluan XueJianhua Hao

Abstract

Long-lasting persistent luminescent nanoparticles (PLNPs) with efficient near-infrared (NIR) emission have emerged as a new generation of probes for in vivo optical bioimaging owing to their advantages of zero-autofluorescence benefited from the self-sustained emission after excitation, deep penetration depth, and a high signal-to-noise ratio. However, most of the PLNPs are charged by ultraviolet (UV) or visible light, remarkably limiting their applications for in vivo long-term bioimaging. Here we demonstrate 980 nm laser activated upconversion-PLNPs (UC-PLNPs) with efficient NIR emission. The NIR-emitting UC-PLNPs (Zn3Ga2GeO8:Yb/Er/Cr) were synthesized by a sol-gel method with subsequent calcination. Owing to the efficient energy-transfer between Er and Cr ions, these UC-PLNPs present long-lasting up to 15 h NIR emission at 700 nm after the excitation of a 980 nm laser; in which both excitation and emission bands fall within the biological transparent window. The results of in vitro/in vivo toxicity assessments indicate that UC-PLNPs after surface modification present low biotoxicity and side effects in living animals. More importantly, the synthesized UC-PLNPs can be effectively recharged by 980 nm laser to restore in vivo p...Continue Reading

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Citations

Aug 2, 2018·Small·Jiajia ZhouJean-Claude G Bünzli
Nov 11, 2018·Advanced Drug Delivery Reviews·Jianhua LiuCyrille Richard
Apr 22, 2021·Journal of Nanobiotechnology·Nian LiuJunpeng Shi
Mar 10, 2020·Nano-micro Letters·Shuqi WuLianbing Zhang
Jul 21, 2021·Chemical Reviews·W Russ AlgarHyungki Kim
Aug 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Caihou LinBinghua Tang
Jan 7, 2022·Chemical Reviews·Bingzhu ZhengXiaogang Liu

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