PMID: 6172274Nov 1, 1981Paper

A-active trisaccharides isolated from A1 and A2 blood-group-specific glycoproteins

European Journal of Biochemistry
A S Donald

Abstract

Blood-group-specific glycoproteins obtained from ovarian cyst fluids of A1 and A2 persons were degraded with NaOH/NaBH4. The oligosaccharides released were de-N-acetylated with Ba(OH)2 and then hydrolysed with dilute H2SO4. The products were fractionated on columns of ion-exchange resin and the components isolated were re-N-acetylated with 14C-labelled acetic anhydride; further purification was effected by paper chromatography. The following trisaccharides: type 1, GalNAc(alpha 1-3)Gal(beta 1-3)GlcNAc; type 2, GalNAc(alpha 1-3)-Gal(beta 1-4)GlcNAc; type 3 (reduced), GalNAc(alpha 1-3)Gal (beta 1-3)GalNAcOH (where Gal is galactose; GalNAc is N-acetylgalactosamine, GlcNAc is N-acetylglucosamine and GalNAcOH is N-acetylgalactosaminitol) were isolated and characterised from both the A1 and A2 materials. The type 3 (reduced) trisaccharide has not previously been obtained from human glycoproteins. Chromatographic evidence indicated that the three trisaccharide structures were also present in other A1, A2, A1B and A2B ovarian cyst glycoproteins and in A1 and A2 salivary glycoproteins. These findings are not indicative of structural differences between the A determinants of A1 and A2 glycoproteins.

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Citations

Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H ClausenS Hakomori
Apr 15, 1983·European Journal of Biochemistry·A Betteridge, W M Watkins
Jan 31, 2009·Acta Histochemica Et Cytochemica·Aki TanakaFukumi Furukawa
Nov 14, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Mizuho NosakaAkihiko Kimura
May 28, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M JeyakanthanL J West
Jan 1, 1986·Vox Sanguinis·R OriolR Mollicone
Jan 1, 1994·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·H ClausenN Grunnet
May 1, 1986·Archives of Biochemistry and Biophysics·G Larson
Jan 24, 2017·International Journal of Biological Macromolecules·Shazia TabasumKhalid Mahmood Zia
Jun 22, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Y LiuH Kimura
Feb 2, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Rozita NaseriMohammad Hosein Farzaei
Aug 1, 1982·European Journal of Biochemistry·J ViitalaT Krusius
Dec 4, 2019·The Journal of Biological Chemistry·Peter Rahfeld, Stephen G Withers
Nov 1, 1988·Biochimie·W M WatkinsP H Johnson
Sep 15, 1983·Biochemical and Biophysical Research Communications·A S DonaldW M Watkins

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