PMID: 6407095Mar 1, 1983Paper

A B-cell proliferation with aberrant true E-rosette formation: a sequential study with a panel of monoclonal antibodies and other surface markers

Scandinavian Journal of Haematology
R J ArmitageJ C Cawley

Abstract

A case of B-CLL in prolymphocytic transformation is described in which large numbers of peripheral blood mononuclear cells possess surface immunoglobulin and rosetted with AET-treated sheep erythrocytes (SIg+E+), but lacked specific T-cell antigens. The SIg (MDGK) was shown to be an intrinsic product of the cell, whose B-cell nature was confirmed by staining with BA1, a specific anti-B-cell monoclonal antibody. The E positivity resembled the rosetting of normal T cells in certain important respects but was weak, and aberrant in certain other respects. Although E rosetting was blocked with anti-chi and anti-D but not with anti-lambda, extensive blocking studies with a panel of monoclonal antibodies indicated that this was due to steric hindrance of weak E receptor rather than specific blocking of SIg possessing anti-E activity. The case is compared and contrasted with previous rare examples of SIg+E+ proliferations and briefly discussed in relation to the recent demonstration that certain non-T cells can express E receptor in vitro.

References

Dec 1, 1978·British Journal of Haematology·A K SinghG Wetherley-Mein
Jul 21, 1977·Nature·G F BurnsJ C Cawley
Jan 1, 1979·British Journal of Haematology·A EnnoD A Galton
Jan 1, 1975·Clinical Immunology and Immunopathology·C C HsuR C Williams
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark
Apr 1, 1980·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Oct 1, 1982·British Journal of Haematology·C P Worman, J C Cawley
Apr 1, 1981·Immunology Today·E L Reinherz, S F Schlossman

❮ Previous
Next ❯

Citations

Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·R FarkasA Klajman
May 1, 1992·British Journal of Haematology·A S KurecF R Davey
Apr 1, 1985·American Journal of Hematology·R J ArmitageJ C Cawley

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.