A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes

American Journal of Human Genetics
F CrucianiP Underhill

Abstract

The variation of 77 biallelic sites located in the nonrecombining portion of the Y chromosome was examined in 608 male subjects from 22 African populations. This survey revealed a total of 37 binary haplotypes, which were combined with microsatellite polymorphism data to evaluate internal diversities and to estimate coalescence ages of the binary haplotypes. The majority of binary haplotypes showed a nonuniform distribution across the continent. Analysis of molecular variance detected a high level of interpopulation diversity (PhiST=0.342), which appears to be partially related to the geography (PhiCT=0.230). In sub-Saharan Africa, the recent spread of a set of haplotypes partially erased pre-existing diversity, but a high level of population (PhiST=0.332) and geographic (PhiCT=0.179) structuring persists. Correspondence analysis shows that three main clusters of populations can be identified: northern, eastern, and sub-Saharan Africans. Among the latter, the Khoisan, the Pygmies, and the northern Cameroonians are clearly distinct from a tight cluster formed by the Niger-Congo-speaking populations from western, central western, and southern Africa. Phylogeographic analyses suggest that a large component of the present Khoisan g...Continue Reading

References

Sep 27, 1991·Science·L VigilantA C Wilson
Oct 1, 1990·Annals of Human Genetics·P MalaspinaG Prantera
Jan 1, 1987·Nature·R L CannA C Wilson
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A Babloyantz, J Hiernaux
Nov 23, 1995·Nature·M F Hammer
Nov 23, 1995·Nature·L S WhitfieldP N Goodfellow
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HoraiN Takahata
Jan 1, 1995·Genetics·D B GoldsteinM W Feldman
Dec 1, 1994·Human Molecular Genetics·M T SeielstadL L Cavalli-Sforza
Jan 1, 1994·Human Molecular Genetics·N MathiasC Tyler-Smith
Oct 1, 1993·Journal of Molecular Evolution·U RitteU Motro
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A UnderhillL L Cavalli-Sforza
Mar 1, 1997·Genetics·M F HammerS L Zegura
Jun 1, 1997·Journal of Molecular Evolution·P MalaspinaA Novelletto
Jan 1, 1997·International Journal of Legal Medicine·M KayserL Roewer
Aug 1, 1997·American Journal of Human Genetics·T K Altheide, M F Hammer
Oct 27, 1997·American Journal of Human Genetics·E WatsonH J Bandelt
Oct 27, 1997·American Journal of Human Genetics·R ScozzariA Novelletto
Apr 16, 1998·American Journal of Human Genetics·G PassarinoA S Santachiara-Benerecetti
Apr 29, 1998·Molecular Biology and Evolution·M F HammerS L Zegura
Jan 9, 1999·American Journal of Physical Anthropology·M M Lahr, R A Foley
Feb 11, 1999·American Journal of Human Genetics·F R SantosR J Mitchell
Feb 26, 1999·Trends in Microbiology·A M VandammeJ Desmyter
Mar 3, 1999·American Journal of Human Genetics·T M KarafetM F Hammer
May 20, 1999·Molecular Biology and Evolution·H J BandeltA Röhl
Sep 29, 1999·American Journal of Physical Anthropology·G SpediniG Paoli
Dec 2, 1999·Nature Genetics·L Quintana-MurciA S Santachiara-Benerecetti
May 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·M F HammerB Bonne-Tamir
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·P ShenP J Oefner
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·R ThomsonM W Feldman
Nov 4, 2000·Nature Genetics·P A UnderhillP J Oefner

❮ Previous
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Citations

Apr 19, 2005·Annals of Hematology·Rute MartinsPaula Faustino
Jan 13, 2006·Human Genetics·Brian McEvoy, Daniel G Bradley
Jun 2, 2005·Human Genetics·Sandra BelezaAntonio Salas
Mar 10, 2010·Human Genetics·Verónica GomesLeonor Gusmão
Sep 6, 2005·Journal of Human Genetics·Carlos FloresAna M Gonzalez
Dec 6, 2005·Journal of Human Genetics·Michael F HammerSatoshi Horai
Mar 25, 2006·Journal of Human Genetics·Erica M Shepard, Rene J Herrera
May 18, 2005·Forensic Science International : Synergy·Valerio OnofriAdriano Tagliabracci
Nov 16, 2002·Current Opinion in Genetics & Development·Laurent Excoffier
Mar 21, 2003·Current Biology : CB·Alec KnightJoanna L Mountain
Aug 21, 2003·Molecular Phylogenetics and Evolution·N Al-ZaheryA S Santachiara-Benerecetti
Nov 30, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Peter J Oefner, Christian G Huber
Dec 25, 2008·European Journal of Human Genetics : EJHG·Vincenza BattagliaOrnella Semino
Aug 26, 2010·European Journal of Human Genetics : EJHG·Martin SikoraJaume Bertranpetit
Jun 24, 2010·European Journal of Human Genetics : EJHG·Andrew Lancaster
Aug 16, 2012·European Journal of Human Genetics : EJHG·Miguel GonzálezLeonor Gusmão
Aug 16, 2012·European Journal of Human Genetics : EJHG·Naser Ansari PourNeil Bradman
Sep 12, 2009·Journal of Human Genetics·Maria C TerrerosRene J Herrera
Jul 22, 2004·Nature Reviews. Genetics·Mark D Shriver, Rick A Kittles
Mar 10, 2005·European Journal of Human Genetics : EJHG·Juan J SanchezNiels Morling
Apr 28, 2005·European Journal of Human Genetics : EJHG·Elizabeth T WoodMichael F Hammer
Jan 25, 2007·European Journal of Human Genetics : EJHG·Turi E KingMark A Jobling
Aug 19, 2007·European Journal of Human Genetics : EJHG·Rihab E BereirMuntaser E Ibrahim
Oct 12, 2007·European Journal of Human Genetics : EJHG·Alicia M CadenasRene J Herrera
Apr 23, 2005·Annals of Human Genetics·A LovellD Labuda
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brenna M HennPeter A Underhill
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brenna M HennMarcus W Feldman
Apr 17, 2009·Molecular Biology and Evolution·Gemma Berniell-LeeDavid Comas
Oct 9, 2009·Molecular Biology and Evolution·Beniamino TrombettaRosaria Scozzari
Mar 9, 2010·Molecular Biology and Evolution·Tatiana M KarafetMichael F Hammer
Nov 27, 2010·Molecular Biology and Evolution·Cesare de FilippoBrigitte Pakendorf
Sep 28, 2006·Proceedings. Biological Sciences·Mark G ThomasHeinrich Härke
Feb 9, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen Oppenheimer
Oct 4, 2003·Genome Research·Analabha BasuPartha P Majumder
Sep 2, 2004·Cold Spring Harbor Symposia on Quantitative Biology·P A Underhill

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