PMID: 9442481Jan 1, 1997Paper

A bacterial model system for understanding multi-drug resistance

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
M H SaierA Matin

Abstract

Mankind stands at the crossroads, recognizing the need for a radical change in bacterial disease management. The development of several antimicrobial agents in the 1940s and 1950s allowed man to gain the upper hand in controlling these diseases. However, the horizon is now clouded by the activation in bacteria of cryptic multi-drug resistance (MDR) genes and the spread of plasmid- and integron-born MDR genes through bacterial populations. Unless remedial measures are taken, nearly all currently available antimicrobial agents are likely to soon lose their efficacies. We briefly review the bacterial MDR phenomenon and focus on a recently emerging family of small multi-drug resistance (SMR) pumps which may provide an ideal model system for understanding the MDR phenomenon in general.

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Citations

Jul 4, 2001·European Journal of Biochemistry·D L JackM H Saier
Jan 12, 2000·Journal of Bacteriology·D ParkeL N Ornston
Jan 5, 2002·Expert Opinion on Investigational Drugs·B M RyanJ F Barrett
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May 20, 2003·Revista Do Instituto De Medicina Tropical De São Paulo·Marcia O PaulaMario J Avila-Campos
Feb 28, 2002·The Journal of Infectious Diseases·Craig W RobertsRima McLeod

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