A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss

Journal of Neuroscience Research
M Angeles Vicente-Torres, J Schacht

Abstract

Acoustic overstimulation induces calcium overload and activation of mitochondria-mediated cell death pathways in outer hair cells (OHC) of the cochlea. However, it is not known whether these events are interrelated or independent. We have recently reported that the calcium-dependent phosphatase calcineurin is activated in OHC following noise exposure and now postulate that calcium overload triggers mitochondria-mediated death pathways through activation of Bcl-2-associated death promoter (BAD) by calcineurin. CBA/J mice were exposed to broadband noise (2-20 kHz), causing a permanent threshold shift of about 40 dB at 12 and 20 kHz, corresponding to damage in the middle and basal turns of the cochlea. Loss of OHC in the basal region was evident in surface preparations. BAD immunostaining in control animals had a cytoplasmic distribution in the cells of the organ of Corti. Five hours after acoustic overstimulation, mitochondria and BAD redistributed to the perinuclear region of OHC in the basal and middle turns but not in the apical turn. The nonapoptotic phospho-BAD (Ser 112) was up-regulated in cells undamaged by noise (supporting cells and inner hair cells) but not in OHC. These data establish a connection between calcium overl...Continue Reading

References

Jan 1, 1991·Cell Motility and the Cytoskeleton·Y Raphael, R A Altschuler
Jan 1, 1986·Hearing Research·D J Lim
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·A FridbergerB Flock
Aug 10, 2000·Trends in Cell Biology·S Desagher, J C Martinou
Sep 17, 2002·Cell Death and Differentiation·G van LooP Vandenabeele
Oct 17, 2002·Journal of the Association for Research in Otolaryngology : JARO·Yong WangM Charles Liberman
Jun 13, 2003·Neuroreport·Xianzhi NiuBarbara Canlon
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Sep 13, 2003·Journal of Neurochemistry·Guang Jian WangStanley A Thayer
Oct 10, 2003·Journal of the Association for Research in Otolaryngology : JARO·Thomas M NicoteraDonald Henderson
Jul 24, 2004·The Journal of Physiology·Haresha SamaranayakeDhasakumar S Navaratnam
Sep 25, 2004·Journal of Neuroscience Research·Shujiro B MinamiJosef M Miller
Oct 27, 2004·Hearing Research·Agneta Viberg, Barbara Canlon
Apr 7, 2005·Hearing Research·Marcus MüllerJean W T Smolders
May 18, 2005·Neurobiology of Disease·Fengshan YuPak H Chan
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carole M HackneyRobert Fettiplace

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Citations

Jan 23, 2008·HNO·S Pfannenstiel, M Praetorius
May 14, 2011·Journal of the Association for Research in Otolaryngology : JARO·Christopher C LiuJohn S Oghalai
Jul 4, 2013·Journal of the Association for Research in Otolaryngology : JARO·Allison B CoffinDavid W Raible
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kevin W ChristieDaniel F Eberl
May 9, 2009·Molecular & Cellular Proteomics : MCP·Thandavarayan KathiresanBernd Sokolowski
Dec 15, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jing ZouHongliang Zheng
Sep 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fu-Quan ChenSu-Hua Sha
Nov 28, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jing ZouIlmari Pyykkö
Oct 27, 2007·Free Radical Research·Xiaorui ShiAlfred Nuttall
Jan 21, 2011·Expert Opinion on Emerging Drugs·Naoki Oishi, Jochen Schacht
Sep 16, 2008·Hearing Research·Kevin K Ohlemiller
Jul 1, 2008·Hearing Research·Guang-Di ChenDonald Henderson
Jan 22, 2010·Journal of Neuroscience Research·Bo Hua Hu, Qunfeng Cai
Jan 31, 2013·Hearing Research·Erik C Böttger, Jochen Schacht
Aug 19, 2015·Frontiers in Cellular Neuroscience·Chao-Hui YangJochen Schacht
Apr 16, 2015·BioMed Research International·Teru KamogashiraTatsuya Yamasoba
Dec 6, 2016·Expert Opinion on Investigational Drugs·Su-Hua Sha, Jochen Schacht
Nov 30, 2016·Journal of the Association for Research in Otolaryngology : JARO·Sarah NeveuxAllison B Coffin
Mar 2, 2016·International Journal of Molecular Sciences·Xing-Xing ZhouWei-Jia Kong
Aug 30, 2018·Physiological Reviews·Jing Wang, Jean-Luc Puel
Oct 19, 2007·Journal of Neuroscience Research·Daisuke YamashitaJosef M Miller
Aug 21, 2018·Neural Plasticity·Muhammad WaqasWenyan Li
Apr 27, 2019·Antioxidants·Chisato Fujimoto, Tatsuya Yamasoba
Oct 8, 2020·International Journal of Radiation Biology·Bruno F E MatarèseCarmel Mothersill
Jun 17, 2021·Communications Biology·Marta SoléMichel André

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