PMID: 6538539Mar 1, 1984Paper

A balance study of 14C-labelled 3H-imidazo[4,5-f]quinolin-2-amines (IQ and MeIQ) in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
P Sjödin, M Jägerstad

Abstract

The absorption and excretion of 14C-labelled 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) were studied in rats of both sexes. The excretion was rapid and within 24 hr more than 90% of the radioactivity had left the rats. After 72 hr the faecal excretion of both compounds was approximately 45-65% and the corresponding excretion via the urine amounted to 37-49%. Only 1-2% was left in the carcasses and less than 0.2% was found in the expired air. About 70% of the IQ and 80% of the MeIQ was found in the bile fluid in a separate 24-hr study. The two compounds had different biliary excretion patterns and the mutagenicity of the bile correlated closely with the excretion of radioactivity.

References

Mar 1, 1980·Cancer Letters·N E SpingarnJ H Weisburger

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Citations

Mar 1, 1991·Mutation Research·H U Aeschbacher, R J Turesky
Oct 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D J DoolittleA W Hayes
Apr 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E OvervikJ A Gustafsson
Oct 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Stavric
Nov 1, 1988·Toxicology Letters·A J Alldrick, I R Rowland
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J A HolmeB Trygg
Jul 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R H Dashwood, M Xu
Mar 22, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Vijaya M LakshmiTerry V Zenser

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