A barrier composed of chemically cross-linked hyaluronic acid (Incert) reduces postoperative adhesion formation

Fertility and Sterility
A F Haney, E Doty

Abstract

To test whether a barrier of chemically cross-linked pure hyaluronic acid reduces postoperative adhesion formation. The material was evaluated in the murine uterine horn model using excision and electrocautery injuries and in animals who had amounts of material inserted into the abdomen to evaluate toxicity. Academic medical center. Mice. Insertion of the barrier between uterine horns and into the peritoneal cavity. Adhesion formation at 14 days; the histology of the peritoneum, liver, and spleen at 42 days; and the number, differential count, morphology, and flow cytometry of peritoneal leukocytes 3 days postoperatively. Fewer adhesions were present when excision injuries were separated by the barrier (12 of 28 sites [43%] versus 23 of 26 control sites [88%]), whereas the number of adhesions was unchanged after electrocautery injuries (14 of 26 sites [54%] versus 17 of 26 control sites [65%]). The uterine horn sites covered by the barrier were histologically indistinguishable from controls. No adverse impact on the peritoneum and peritoneal fluid leukocyte population was observed with barrier insertion. The use of a barrier composed of a chemically cross-linked hyaluronic acid derivative (Incert, Anika Therapeutics, Inc., Wobu...Continue Reading

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