A Basal chordate model for studies of gut microbial immune interactions.

Frontiers in Immunology
Larry J DishawGary W Litman

Abstract

Complex symbiotic interactions at the surface of host epithelia govern most encounters between host and microbe. The epithelium of the gut is a physiologically ancient structure that is comprised of a single layer of cells and is thought to possess fully developed immunological capabilities. Ciona intestinalis (sea squirt), which is a descendant of the last common ancestor of all vertebrates, is a potentially valuable model for studying barrier defenses and gut microbial immune interactions. A variety of innate immunological phenomena have been well characterized in Ciona, of which many are active in the gut tissues. Interactions with gut microbiota likely involve surface epithelium, secreted immune molecules including variable region-containing chitin-binding proteins, and hemocytes from a densely populated laminar tissue space. The microbial composition of representative gut luminal contents has been characterized by molecular screening and a potentially relevant, reproducible, dysbiosis can be induced via starvation. The dialog between host and microbe in the gut can be investigated in Ciona against the background of a competent innate immune system and in the absence of the integral elements and processes that are character...Continue Reading

Citations

Nov 21, 2013·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yongzhong LuJie Liu
Jul 2, 2014·Developmental and Comparative Immunology·Larry J DishawWilliam Parker
Mar 2, 2016·Environmental Microbiology Reports·Patrick L CahillSusanna A Wood
Mar 22, 2019·Frontiers in Immunology·Assunta LibertiLarry J Dishaw
Feb 2, 2021·Chemical Reviews·Jasmin PortelinhaAlfredo M Angeles-Boza

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Methods Mentioned

BETA
PCR

Software Mentioned

Ciona

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