A basic helix-loop-helix transcription factor CabHLH113 positively regulate pepper immunity against Ralstonia solanacearum.

Microbial Pathogenesis
Ansar HussainYunhao Sun

Abstract

Pepper's (Capsicum annum) response to bacterial pathogen Ralstonia solanacearm inoculation (RSI) and abiotic stresses is known to be synchronized by transcriptional network; however, related molecular mechanisms need extensive experimentation. We identified and characterized functions of CabHLH113 -a basic helix-loop-helix transcription factor-in pepper immunity to R. solanacearum infection. The RSI and foliar spray of phytohormones, including salicylic acid (SA), methyl jasmonate (MeJA), ethylene (ETH), and absicic acid (ABA) induced transcription of CabHLH113 in pepper. Loss of function of CabHLH113 by virus-induced-gene-silencing (VIGS) compromised defense of pepper plants against RSI and suppressed relative expression levels of immunity-associated marker genes, i.e., CaPR1, CaNPR1, CaDEF1, CaHIR1 and CaABR1. Pathogen growth was significantly increased after loss of function of CabHLH113 compared with un-silenced plants with remarkable increase in pepper susceptibility. Besides, transiently over-expression of CabHLH113 induced HR-like cell death, H2O2 accumulation and up-regulation of defense-associated marker genes, e.g. CaPR1, CaNPR1, CaDEF1, CaHIR1 and CaABR1. Additionally, transient over-expression of CabHLH113 enhanced ...Continue Reading

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