PMID: 7524336Sep 1, 1994Paper

A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells

The American Journal of Physiology
G ValentiD Brown

Abstract

The water channel CHIP28 accounts for the high water permeability of proximal tubules and thin descending limbs of Henle; a homologous water channel, WCH-CD, in the apical membrane of collecting duct principal cells, may be the vasopressin-sensitive water channel. We show here that one antiserum, raised against CHIP28, immunostains the basolateral membrane of collecting duct principal cells, in addition to staining CHIP28 in other cells. This serum was named anti-basolateral integral protein (anti-BLIP) to distinguish it from other anti-CHIP28 antisera. By Western blotting, BLIP serum recognized both CHIP28 and MIP26, and it stained lens fibers, which contain MIP26 but not CHIP28. BLIP antiserum immunoprecipitated a 28-kDa band, a broad 35- to 50-kDa band, and an approximately 16-kDa band from kidney papilla. It also stained the basolateral membrane of gastric parietal cells, which were not stained with anti-CHIP28 or anti-MIP26 antibodies. BLIP antiserum immunoprecipitated a 28-kDa protein band from stomach; this protein was not precipitated by anti-CHIP28 antibodies. These results suggest that basolateral membranes of principal cells and parietal cells contain a protein(s) that shares common epitopes with CHIP28 and MIP26. Fi...Continue Reading

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Citations

Dec 19, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M KoyamaB A Schulte
Jul 1, 1995·Histochemistry and Cell Biology·D BrownI Sabolic
Sep 1, 1994·The Clinical Investigator·I Sabolić, D Brown
Mar 21, 1998·The Journal of Biological Chemistry·W LuoE G Kranias
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·T SonnentagU Seidler
Jan 12, 2007·Cardiovascular Drug Reviews·A Lochner, J A Moolman
Oct 16, 2004·Archives of Insect Biochemistry and Physiology·Sabrina V MartiniMarcelo M Morales
Oct 6, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C SilbersteinC Ibarra
Jan 7, 2000·Biochemical and Biophysical Research Communications·E J MayerE McKenna
Oct 21, 1999·Biochemical and Biophysical Research Communications·A XuN Narayanan
Aug 1, 1995·Current Opinion in Cell Biology·P AgreS Nielsen
Oct 1, 1995·Kidney International·A S VerkmanT Ma

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