A Bayesian method for simultaneously detecting Mendelian and imprinted quantitative trait loci in experimental crosses of outbred species.

Genetics
Takeshi Hayashi, Takashi Awata

Abstract

Genomic imprinting is interpreted as a phenomenon, in which some genes inherited from one parent are not completely expressed due to modification of the genome caused during gametogenesis. Subsequently, the expression level of an allele at the imprinted gene is changed dependent on the parental origin, which is referred to as the parent-of-origin effect. In livestock, some QTL for reproductive performance and meat productivity have been reported to be imprinted. So far, methods detecting imprinted QTL have been proposed on the basis of interval mapping, where only a single QTL was tested at a time. In this study, we developed a Bayesian method for simultaneously mapping multiple QTL, allowing the inference about expression modes of QTL in an outbred F2 family. The inference about whether a QTL is Mendelian or imprinted was made using Markov chain Monte Carlo estimation by comparing the goodness-of-fits between models, assuming the presence and the absence of parent-of-origin effect at a QTL. We showed by the analyses of simulated data sets that the Bayesian method can effectively detect both Mendelian QTL and imprinted QTL.

References

Oct 27, 1997·American Journal of Human Genetics·S C Heath
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·D J de KoningM A Groenen
Mar 17, 2001·Nature Reviews. Genetics·W Reik, J Walter
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Nov 16, 2004·Molecular Biotechnology·Ellen M Wijsman, Dongmei Yu
Jan 25, 2005·Genetical Research·Maria Tuiskula-HaavistoJohanna Vilkki

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Citations

Jan 10, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Marco C A M BinkOscar S Smith
Feb 22, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Shize LiRunqing Yang
Nov 8, 2012·Journal of Applied Genetics·Huijiang GaoDaniel R Prows

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