A Bayesian mixture modeling approach for assessing the effects of correlated exposures in case-control studies

Journal of Exposure Science & Environmental Epidemiology
Frank de VochtJon Wakefield

Abstract

Predisposition to a disease is usually caused by cumulative effects of a multitude of exposures and lifestyle factors in combination with individual susceptibility. Failure to include all relevant variables may result in biased risk estimates and decreased power, whereas inclusion of all variables may lead to computational difficulties, especially when variables are correlated. We describe a Bayesian Mixture Model (BMM) incorporating a variable-selection prior and compared its performance with logistic multiple regression model (LM) in simulated case-control data with up to twenty exposures with varying prevalences and correlations. In addition, as a practical example we re analyzed data on male infertility and occupational exposures (Chaps-UK). BMM mean-squared errors (MSE) were smaller than of the LM, and were independent of the number of model parameters. BMM type I errors were minimal (≤1), whereas for the LM this increased with the number of parameters and correlation between exposures. The numbers of type II errors were comparable. Re analysis of Chaps-UK data demonstrated more convincingly than by using a LM that occupational exposure to glycol ethers and VOCs are likely risk factors for male infertility. This BMM proves...Continue Reading

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Citations

Jan 29, 2014·Journal of Epidemiology and Community Health·Karyn HeavnerIgor Burstyn
Oct 23, 2014·International Journal of Environmental Research and Public Health·Igor BurstynA Robert Schnatter
May 15, 2015·Environmental Health : a Global Access Science Source·Michael D SwartzPhilip J Lupo
Nov 19, 2015·International Journal of Environmental Research and Public Health·Frank de VochtKate Tilling
Mar 23, 2018·Journal of Epidemiology and Community Health·Pooja JainMarc Chadeau-Hyam
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Aude LacourtPatrick Brochard
Feb 16, 2019·International Journal of Environmental Research and Public Health·Brendan A BernardoLawrence C McCandless
Apr 4, 2021·International Journal of Environmental Research and Public Health·David C WheelerCatherine Metayer

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