A Bayesian model for detecting past recombination events in DNA multiple alignments

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
G McGuireM J Prentice


Most phylogenetic tree estimation methods assume that there is a single set of hierarchical relationships among sequences in a data set for all sites along an alignment. Mosaic sequences produced by past recombination events will violate this assumption and may lead to misleading results from a phylogenetic analysis due to the imposition of a single tree along the entire alignment. Therefore, the detection of past recombination is an important first step in an analysis. A Bayesian model for the changes in topology caused by recombination events is described here. This model relaxes the assumption of one topology for all sites in an alignment and uses the theory of Hidden Markov models to facilitate calculations, the hidden states being the underlying topologies at each site in the data set. Changes in topology along the multiple sequence alignment are estimated by means of the maximum a posteriori (MAP) estimate. The performance of the MAP estimate is assessed by application of the model to data sets of four sequences, both simulated and real.


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Related Concepts

Bayesian Prediction
DNA, Double-Stranded
DNA, Bacterial
Markov Chains
Recombination, Genetic
Two-Parameter Models
Determination, Sequence Homology

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