A Bayesian semiparametric Markov regression model for juvenile dermatomyositis

Statistics in Medicine
Maria De IorioL R Wedderburn

Abstract

Juvenile dermatomyositis (JDM) is a rare autoimmune disease that may lead to serious complications, even to death. We develop a 2-state Markov regression model in a Bayesian framework to characterise disease progression in JDM over time and gain a better understanding of the factors influencing disease risk. The transition probabilities between disease and remission state (and vice versa) are a function of time-homogeneous and time-varying covariates. These latter types of covariates are introduced in the model through a latent health state function, which describes patient-specific health over time and accounts for variability among patients. We assume a nonparametric prior based on the Dirichlet process to model the health state function and the baseline transition intensities between disease and remission state and vice versa. The Dirichlet process induces a clustering of the patients in homogeneous risk groups. To highlight clinical variables that most affect the transition probabilities, we perform variable selection using spike and slab prior distributions. Posterior inference is performed through Markov chain Monte Carlo methods. Data were made available from the UK JDM Cohort and Biomarker Study and Repository, hosted a...Continue Reading

References

Aug 1, 1995·British Journal of Rheumatology·D P SymmonsS M Davis
Jun 10, 2003·Arthritis and Rheumatism·Eduardo P MendezUNKNOWN NIAMS Juvenile DM Registry Physician Referral Group
Sep 2, 2004·Biometrics·Odd O AalenEinar Husebye
Jul 12, 2008·Statistics in Medicine·Ardo van den Hout, Fiona E Matthews
Feb 12, 2011·Current Rheumatology Reports·Michelle Batthish, Brian M Feldman
Nov 15, 2011·Statistical Methods in Medical Research·Ardo van den HoutRinke H Klein Entink
Jan 26, 2012·Statistics in Medicine·Veronika RockovaBob Löwenberg
Jun 28, 2012·Annals of the Rheumatic Diseases·Dragana LazarevicUNKNOWN Paediatric Rheumatology International Trials Organisation (PRINTO)
Oct 30, 2013·International Journal of Rheumatic Diseases·Peter J GowdieJonathan D Akikusa
Mar 7, 2014·Pharmaceutical Research·Sebastian UeckertUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 18, 2016·Arthritis Care & Research·Raquel Campanilho-MarquesUNKNOWN Juvenile Dermatomyositis Research Group
Dec 31, 2016·Computers in Biology and Medicine·Shiwen ShenWilliam Hsu

❮ Previous
Next ❯

Citations

Oct 12, 2020·Statistics in Medicine·Nicolò MargaritellaRuth King

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.