A Bayesian supervised dual-dimensionality reduction model for simultaneous decoding of LFP and spike train signals

Stat : the ISI's Journal for Rapid Dissemination of Statistics Research
Andrew HolbrookBabak Shahbaba

Abstract

Neuroscientists are increasingly collecting multimodal data during experiments and observational studies. Different data modalities-such as EEG, fMRI, LFP, and spike trains-offer different views of the complex systems contributing to neural phenomena. Here, we focus on joint modeling of LFP and spike train data, and present a novel Bayesian method for neural decoding to infer behavioral and experimental conditions. This model performs supervised dual-dimensionality reduction: it learns low-dimensional representations of two different sources of information that not only explain variation in the input data itself, but also predict extra-neuronal outcomes. Despite being one probabilistic unit, the model consists of multiple modules: exponential PCA and wavelet PCA are used for dimensionality reduction in the spike train and LFP modules, respectively; these modules simultaneously interface with a Bayesian binary regression module. We demonstrate how this model may be used for prediction, parametric inference, and identification of influential predictors. In prediction, the hierarchical model outperforms other models trained on LFP alone, spike train alone, and combined LFP and spike train data. We compare two methods for modeling ...Continue Reading

References

Mar 30, 2001·Journal of Chemical Information and Computer Sciences·M G Gustafsson
Apr 8, 2006·Neuron·George Dragoi, György Buzsáki
Jun 19, 2012·Nature Neuroscience·Anoopum S GuptaA David Redish
Oct 14, 2014·Scandinavian Journal of Statistics, Theory and Applications·Simon Byrne, Mark Girolami
Feb 5, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy A AllenNorbert J Fortin

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Citations

Mar 15, 2020·The International Journal of Biostatistics·Edward H Kennedy
Nov 2, 2017·Statistical Applications in Genetics and Molecular Biology·Panagiotis Papastamoulis, Magnus Rattray
Jan 1, 2017·Biostatistics & Epidemiology·Xiaoxia HanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 17, 2020·JCO Global Oncology·Prashant MathurUNKNOWN ICMR-NCDIR-NCRP Investigator Group
Jan 1, 2018·Journal of Statistical Computation and Simulation·Andrew HolbrookBabak Shahbaba
Jun 26, 2021·Journal of Computational and Graphical Statistics : a Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·Andrew J HolbrookMarc A Suchard

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