PMID: 6413985Jul 1, 1983Paper

A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788

Pharmacology, Biochemistry, and Behavior
J FeldonM Myslobodsky

Abstract

The potential "anxiogenic" effects of convulsant benzodiazepine and GABA-antagonist, Ro 5-3663 and specific antagonist of benzodiazepine receptors, Ro 15-1788 were compared in the Geller-Seifter conflict paradigm. Chlordiazepoxide (CDP) (5 mg/kg) was used as a "positive" control. Both Ro 5-3663 (1 mg/kg) and Ro 15-1788 (10 mg/kg) antagonized the anticonflict effect of CDP. However, while Ro 15-1788 had a modest anticonflict potency. Ro 5-3663 had an anxiogenic effect in its own right.

References

Jul 1, 1969·Electroencephalography and Clinical Neurophysiology·N W Grandstaff
May 1, 1982·Pharmacology, Biochemistry, and Behavior·J Feldon, M Myslobodsky
Apr 9, 1981·Nature·W HunkelerW Haefely
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·F ZambottiP Mantegazza
Apr 1, 1964·Electroencephalography and Clinical Neurophysiology·C D CLEMENTEW WYRWICKA

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Citations

Jan 17, 1989·European Journal of Pharmacology·R J Marley, D W Gallager
Aug 1, 1986·Pharmacology, Biochemistry, and Behavior·M GalizioB A Spencer
Jan 1, 1987·Pharmacology, Biochemistry, and Behavior·T Yamamoto, S Ueki
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S J Cooper, L B Estall
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·R A Shephard
Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·J M WitkinJ E Barrett
Mar 1, 1983·Pflügers Archiv : European journal of physiology·C N Scholfield
Oct 23, 2014·Trauma Monthly·Shervin AssariMarc A Zimmerman

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