A beta-arrestin 2 signaling complex mediates lithium action on behavior

Cell
Jean-Martin BeaulieuMarc G Caron

Abstract

Besides their role in desensitization, beta-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta-arrestin 2, and protein phosphatase 2A. When administered to beta-arrestin 2 knockout mice, lithium fails to affect Akt/GSK3 signaling and induce behavioral changes associated with GSK3 inhibition as it does in normal animals. These results point toward a pharmacological approach to modulating GPCR function that affects the formation of beta-arrestin-mediated signaling complexes.

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J LohseJ L Benovic
Jul 30, 1971·Nature·C CoxM Tomkiewicz
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Klein, D A Melton
Apr 8, 1998·Current Opinion in Genetics & Development·D R Alessi, P Cohen
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·E Chalecka-Franaszek, D M Chuang
Sep 25, 1999·The Journal of Biological Chemistry·L LavoieB I Posner
Feb 13, 2001·Biochemical and Biophysical Research Communications·W J Ryves, A J Harwood
May 23, 2003·Nature·Christopher J PhielPeter S Klein
Nov 7, 2003·The Journal of Biological Chemistry·Sébastien MarionMarc G Caron
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua LiRichard S Jope
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jean-Martin BeaulieuMarc G Caron
Jun 26, 2004·Annual Review of Neuroscience·Raul R GainetdinovMarc G Caron
Jun 29, 2004·Pharmacology, Biochemistry, and Behavior·James J CrowleyIrwin Lucki
Aug 19, 2004·The International Journal of Neuropsychopharmacology·Todd D GouldHusseini K Manji
May 5, 2006·The International Journal of Neuropsychopharmacology·Xiaohua LiKevin A Roth
Jun 21, 2006·The International Journal of Neuropsychopharmacology·Jean-Martin Beaulieu
Jul 29, 2006·Science·Noelia V WeisstaubJay A Gingrich
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jos PrickaertsThomas Steckler
Sep 7, 2006·The Journal of Biological Chemistry·Jean-Martin BeaulieuMarc G Caron
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Keshava RajagopalRobert J Lefkowitz
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Martin BeaulieuMarc G Caron
Feb 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Todd D GouldHusseini K Manji
Feb 20, 2007·Annual Review of Physiology·Richard T Premont, Raul R Gainetdinov
Mar 14, 2007·Trends in Pharmacological Sciences·Jean-Martin BeaulieuMarc G Caron

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Citations

Nov 6, 2010·Archives of Pharmacal Research·Dong Im ChoKyeong-Man Kim
Apr 5, 2011·Journal of Physiology and Biochemistry·Anton TerasmaaEero Vasar
Jun 4, 2013·Journal of Medicinal Chemistry·Hendra GunosewoyoAlan P Kozikowski
Dec 4, 2012·Nature Medicine·Amantha ThathiahBart De Strooper
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Jul 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua Li, Richard S Jope
Nov 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Prem N YadavBryan L Roth
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua LiRichard C Shelton
Mar 11, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jen Q PanStephen J Haggarty
May 1, 2010·Nature Reviews. Drug Discovery·Sudarshan RajagopalRobert J Lefkowitz
Oct 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jiyuan Sun, Xin Lin
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bernard MasriMarc G Caron
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jane E MurphyNigel W Bunnett
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yuting LiLan Ma
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·John A AllenJian Jin
Nov 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nikhil M UrsMarc G Caron
Aug 12, 2010·Behavioural Pharmacology·Livia PasqualiFrancesco Fornai
Aug 8, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Alexander R Moschen, Herbert Tilg
Oct 2, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Isabelle A Leclercq, Yves Horsmans
Feb 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Robin E Duncan, Richard P Bazinet
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Camille LatapyJean-Martin Beaulieu
Mar 21, 2009·Molecular Pharmacology·Jamie L McConnell, Brian E Wadzinski
Apr 30, 2010·Pharmacological Reviews·Louis M Luttrell, Diane Gesty-Palmer
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Sep 1, 2011·Science Signaling·Anutosh ChakrabortySolomon H Snyder
Oct 22, 2008·Annual Review of Pharmacology and Toxicology·Jean-Martin BeaulieuMarc G Caron
May 24, 2008·The Journal of Clinical Investigation·P Alexander Arguello, Joseph A Gogos
Oct 3, 2008·The Journal of Clinical Investigation·Risto KerkelaGordon S Huggins
Mar 11, 2009·The Journal of Clinical Investigation·Seongah HanAlan R Tall
Jun 10, 2010·The Journal of Clinical Investigation·Raquel Gómez-Sintes, José J Lucas
Aug 9, 2011·The Journal of Clinical Investigation·W Timothy O'BrienPeter S Klein
Dec 3, 2013·The Journal of Clinical Investigation·Herbert Y Meltzer, Bryan L Roth
Nov 21, 2009·Molecular Brain·Oksana Kaidanovich-BeilinJames R Woodgett
Nov 30, 2012·Molecular Brain·Frances Fangjia LuZafiris J Daskalakis
Oct 27, 2010·PloS One·Tatyana D SotnikovaRaul R Gainetdinov
Aug 23, 2012·PloS One·Wenjun ZhouXiaohua Li
Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atheir I AbbasBryan L Roth

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