A better parameter in predicting insulin resistance: obesity plus elevated alanine aminotransferase.

World Journal of Gastroenterology : WJG
Ping-Hao ChenYu-Cheng Lin

Abstract

To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. We enrolled a total of 1308 male workers aged from 22 to 63 years. Data was extracted from the workers' periodic health check-ups in hospitals. All cases were from the community of northern Taiwan. This was a cross-sectional observational study from July to September in 2004. We grouped all cases into four groups, based on the quartile of homeostasis model assessment. The top fourth quartile group was defined as the group with insulin resistance. We performed multivariate logistic regression analysis for the odds ratio of the risk factors for insulin resistance. Compared with metabolic syndrome, the coexistence of both factors had a 4.3-fold (95% CI: 2.7-6.8) increased risk, which was more than metabolic syndrome with a 3.6-fold (95% CI: 2.6-5.0) increased risk. The two factors had a synergistic effect. The synergistic index of obesity and elevated alanine aminotransferase (ALT) was 2.1 (95% CI: 1.01-4.3). Obesity and elevated ALT are associated with insulin resistance. The effects are synergistic. Coexistence of them is better than metabolic syndrome in predicting insulin re...Continue Reading

References

Dec 1, 1983·The Journal of Clinical Endocrinology and Metabolism·W P Newman, R G Brodows
Apr 27, 2000·The New England Journal of Medicine·D S Pratt, M M Kaplan
Jun 19, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·N F Chu
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Nov 3, 2004·Circulation·Robert H EckelUNKNOWN American Heart Association
Nov 4, 2004·The Journal of Clinical Endocrinology and Metabolism·Jerry R GreenfieldLesley V Campbell
Dec 23, 2004·Archives of Disease in Childhood·R M VinerP Hindmarsh
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Oct 26, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N-F Chu
Nov 11, 2005·The American Journal of Clinical Nutrition·Hye Soon ParkSeon Mee Kim
Jul 11, 2006·The Journal of Clinical Investigation·Takashi KadowakiKazuyuki Tobe
Aug 17, 2006·The Journal of Clinical Endocrinology and Metabolism·Tania S BurgertSonia Caprio
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Kristina M Utzschneider, Steven E Kahn
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Jan 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Rubén E Quirós-TejeiraNancy F Butte
May 15, 2007·Gastroenterology·Steven E ShoelsonAfia Naaz
May 29, 2007·Diabetes Care·Zachary T Bloomgarden
Jul 25, 2007·Immunology and Cell Biology·Andisheh Abedini, Steven E Shoelson
Apr 11, 2008·Nature Reviews. Molecular Cell Biology·Adilson GuilhermeMichael P Czech
Nov 14, 2008·Chronobiology International·Francesco PortaluppiMichael H Smolensky

❮ Previous
Next ❯

Citations

Sep 6, 2012·BMC Endocrine Disorders·Miguel Angel Gómez-SámanoAlfonso Gulias-Herrero
Sep 4, 2012·Metabolism: Clinical and Experimental·Peng-Tzu LiuJong-Dar Chen
Dec 20, 2011·Clinical Biochemistry·Amitabha Ray, Margot P Cleary
Oct 26, 2011·Journal of Clinical Nursing·Li-Jan WuJen-Chen Tsai
Sep 14, 2013·Mitochondrion·M AdevaC Donapetry
Sep 7, 2011·Preventive Medicine·James TsaiJanet B Croft
Dec 18, 2019·The Journal of Clinical Endocrinology and Metabolism·Victoria HigginsKhosrow Adeli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.